(S)-1-(2-(difluoromethyl)pyridin-4-yl)-4-fluoro-1-(3-(pyrimidin-5-yl)phenyl)-1H-isoindol-3-amine

Base Information

• Chemical Name: (S)-1-(2-(difluoromethyl)pyridin-4-yl)-4-fluoro-1-(3-(pyrimidin-5-yl)phenyl)-1H-isoindol-3-amine
• CAS No.: 1227163-84-9
• Molecular Formula: C₂₄H₁₆F₃N₅
• Molecular Weight: 431.42
• Mol file: 1227163-84-9.mol

Synonyms:AZD₃₈₃₉

Chemical Property of (S)-1-(2-(difluoromethyl)pyridin-4-yl)-4-fluoro-1-(3-(pyrimidin-5-yl)phenyl)-1H-isoindol-3-amine

Chemical Property:

• Boiling Point: 596.3±60.0 °C(Predicted)
• PKA: 2.56±0.40(Predicted)
• Density: 1.41±0.1 g/cm3(Predicted)

Purity/Quality:

99%, ^*data from raw suppliers

AZD3839 >98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-1-(2-(difluoromethyl)pyridin-4-yl)-4-fluoro-1-(3-(pyrimidin-5-yl)phenyl)-1H-isoindol-3-amine

There total 2 articles about (S)-1-(2-(difluoromethyl)pyridin-4-yl)-4-fluoro-1-(3-(pyrimidin-5-yl)phenyl)-1H-isoindol-3-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(3-bromophenyl)-1-(2-(difluoromethyl)pyridin-4-yl)-4-fluoro-1H-isoindol-3-amine hemifumarate + pyrimidine 5-boronic acid (109299-78-7) → (1R)-1-(2-(difluoromethyl)pyridin-4-yl)-4-fluoro-1-(3-(pyrimidin-5-yl)phenyl)-1H-isoindol-3-amine (1227164-02-4) + AZD3839 (1227163-84-9)

Guidance literature:

With potassium carbonate; 3-(di-tert-butylphosphino)-propane-1-sulfonic acid; palladium diacetate; In water; butan-1-ol; at 80 ℃; Inert atmosphere;

Reference yield:

AZD3839 (1227163-83-8) → (1R)-1-(2-(difluoromethyl)pyridin-4-yl)-4-fluoro-1-(3-(pyrimidin-5-yl)phenyl)-1H-isoindol-3-amine (1227164-02-4) + AZD3839 (1227163-84-9)

Guidance literature:

With Chiracel OD; In methanol; carbon dioxide; diethylamine; Resolution of racemate;

Reference yield:

AZD3839 (1227163-84-9) + (2E)-but-2-enedioic acid (110-17-8,26099-09-2) → (S)-1-(2-(difluoromethyl)pyridin-4-yl)-4-fluoro-1-(3-(pyrimidin-5-yl)phenyl)-1H-isoindol-3-amine hemifumarate

Guidance literature:

In ethyl acetate; at 50 ℃; for 528h; Product distribution / selectivity; Inert atmosphere;

upstream raw materials:

AZD₃₈₃₉

pyrimidine 5-boronic acid

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1227163-84-9 (S)-1-(2-(difluoromethyl)pyridin-4-yl)-4-fluoro-1-(3-(pyrimidin-5-yl)phenyl)-1H-isoindol-3-amine

Send

Send

Metric Ton KG G Pound L ML

Send

Send