(1R,2S,3S)-3-Benzenesulfonyl-2-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-5-methylene-cyclopentanecarboxylic acid ethyl ester

Base Information

Chemical Name:(1R,2S,3S)-3-Benzenesulfonyl-2-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-5-methylene-cyclopentanecarboxylic acid ethyl ester
CAS No.:123488-13-1
Molecular Formula:C₂₀H₂₆O₆S
Molecular Weight:394.489
Hs Code.:

Synonyms:(1R,2S,3S)-3-Benzenesulfonyl-2-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-5-methylene-cyclopentanecarboxylic acid ethyl ester

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Chemical Property of (1R,2S,3S)-3-Benzenesulfonyl-2-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-5-methylene-cyclopentanecarboxylic acid ethyl ester

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Technology Process of (1R,2S,3S)-3-Benzenesulfonyl-2-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-5-methylene-cyclopentanecarboxylic acid ethyl ester

There total 2 articles about (1R,2S,3S)-3-Benzenesulfonyl-2-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-5-methylene-cyclopentanecarboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 123538-57-8
(1R,2S,3S)-3-Benzenesulfonyl-2-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-5-methylene-cyclopentanecarboxylic acid

: 122-52-1
triethyl phosphite

: 123488-13-1
(1R,2S,3S)-3-Benzenesulfonyl-2-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-5-methylene-cyclopentanecarboxylic acid ethyl ester

Guidance literature:: With diethylazodicarboxylate; In 1,2-dimethoxyethane; for 12h; Ambient temperature;
DOI:10.1021/ja00201a032

Reference yield:

: 100289-50-7
(E)-(4'S)-2-(2',2'-dimethyl-1',3'-dioxalan-4'-yl)vinyl phenyl sulphone

: 123488-13-1
(1R,2S,3S)-3-Benzenesulfonyl-2-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-5-methylene-cyclopentanecarboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 64 percent / (i-C₃H₇O)3P, Pd(OAc)2 / toluene / 6 h / 80 °C

2: 73 percent / diethyl azodicarboxylate / 1,2-dimethoxy-ethane / 12 h / Ambient temperature

With diethylazodicarboxylate; palladium diacetate; triisopropyl phosphite; In 1,2-dimethoxyethane; toluene;
DOI:10.1021/ja00201a032