Technology Process of C21H26ClNO3
There total 6 articles about C21H26ClNO3 which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
C18H23NO;
With
lithium diisopropyl amide;
In
tetrahydrofuran;
at -78 ℃;
for 0.5h;
Inert atmosphere;
Nitriloacetic acid 2-chloro-ethyl ester;
With
N,N,N,N,N,N-hexamethylphosphoric triamide;
In
tetrahydrofuran;
for 4h;
Inert atmosphere;
With
water;
In
tetrahydrofuran;
DOI:10.1021/ol201122f
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: potassium hydroxide / ethanol / 4 h / 80 °C / Inert atmosphere
1.2: 20 °C / Saturated solution
2.1: tetra(n-butyl)ammonium hydroxide / water; toluene / 1.5 h / 50 °C / Inert atmosphere
3.1: lithium diisopropyl amide / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere
3.2: 4 h / Inert atmosphere
With
tetra(n-butyl)ammonium hydroxide; potassium hydroxide; lithium diisopropyl amide;
In
tetrahydrofuran; ethanol; water; toluene;
DOI:10.1021/ol201122f
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: tetra(n-butyl)ammonium hydroxide / water; toluene / 1.5 h / 50 °C / Inert atmosphere
2.1: lithium diisopropyl amide / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere
2.2: 4 h / Inert atmosphere
With
tetra(n-butyl)ammonium hydroxide; lithium diisopropyl amide;
In
tetrahydrofuran; water; toluene;
DOI:10.1021/ol201122f