(E)-ethyl 2-(5-fluoro-1-((4-methyl-2-phenylpyrimidin-5-yl)methylene)-1H-inden-3-yl)-2-methyl propanoate

Base Information

Chemical Name:(E)-ethyl 2-(5-fluoro-1-((4-methyl-2-phenylpyrimidin-5-yl)methylene)-1H-inden-3-yl)-2-methyl propanoate
CAS No.:1361001-12-8
Molecular Formula:C₂₇H₂₅FN₂O₂
Molecular Weight:428.506
Hs Code.:

Synonyms:(E)-ethyl 2-(5-fluoro-1-((4-methyl-2-phenylpyrimidin-5-yl)methylene)-1H-inden-3-yl)-2-methyl propanoate

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Chemical Property of (E)-ethyl 2-(5-fluoro-1-((4-methyl-2-phenylpyrimidin-5-yl)methylene)-1H-inden-3-yl)-2-methyl propanoate

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Technology Process of (E)-ethyl 2-(5-fluoro-1-((4-methyl-2-phenylpyrimidin-5-yl)methylene)-1H-inden-3-yl)-2-methyl propanoate

There total 4 articles about (E)-ethyl 2-(5-fluoro-1-((4-methyl-2-phenylpyrimidin-5-yl)methylene)-1H-inden-3-yl)-2-methyl propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 342405-36-1
4-methyl-2-phenyl-5-pyrimidinecarboxaldehyde

: 1361000-79-4
ethyl 2-(5-fluoro-1H-inden-3-yl)-2-methylpropanoate

: 1361001-12-8
(E)-ethyl 2-(5-fluoro-1-((4-methyl-2-phenylpyrimidin-5-yl)methylene)-1H-inden-3-yl)-2-methyl propanoate

Guidance literature:: With sodium hydroxide; In methanol; at 20 - 70 ℃;
DOI:10.1021/jm201528b

Reference yield:

: 1361000-76-1
ethyl 2-(6-fluoro-1-hydroxy-2,3-dihydro-1H-inden-1-yl)-2-methylpropanoate

: 1361001-12-8
(E)-ethyl 2-(5-fluoro-1-((4-methyl-2-phenylpyrimidin-5-yl)methylene)-1H-inden-3-yl)-2-methyl propanoate

Guidance literature:: Multi-step reaction with 2 steps

1: toluene-4-sulfonic acid; calcium chloride / toluene / 16 h / Reflux

2: sodium hydroxide / methanol / 20 - 70 °C

With toluene-4-sulfonic acid; calcium chloride; sodium hydroxide; In methanol; toluene;
DOI:10.1021/jm201528b

Reference yield:

: 1481-32-9
6-fluoroindan-1-one

: 1361001-12-8
(E)-ethyl 2-(5-fluoro-1-((4-methyl-2-phenylpyrimidin-5-yl)methylene)-1H-inden-3-yl)-2-methyl propanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium diisopropyl amide / tetrahydrofuran / 0.33 h / -75 °C / Inert atmosphere

1.2: 2 h / -75 °C / Inert atmosphere

2.1: toluene-4-sulfonic acid; calcium chloride / toluene / 16 h / Reflux

3.1: sodium hydroxide / methanol / 20 - 70 °C

With toluene-4-sulfonic acid; calcium chloride; sodium hydroxide; lithium diisopropyl amide; In tetrahydrofuran; methanol; toluene;
DOI:10.1021/jm201528b