4-cyclohexyl-3-hydroxy-2-methylene-N-phenyl-4-<(trimethylsilyl)oxy>butanamide

Base Information

Chemical Name:4-cyclohexyl-3-hydroxy-2-methylene-N-phenyl-4-<(trimethylsilyl)oxy>butanamide
CAS No.:103633-69-8
Molecular Formula:C₂₀H₃₁NO₃Si
Molecular Weight:361.557
Hs Code.:

Synonyms:4-cyclohexyl-3-hydroxy-2-methylene-N-phenyl-4-<(trimethylsilyl)oxy>butanamide

Suppliers and Price of 4-cyclohexyl-3-hydroxy-2-methylene-N-phenyl-4-<(trimethylsilyl)oxy>butanamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-cyclohexyl-3-hydroxy-2-methylene-N-phenyl-4-<(trimethylsilyl)oxy>butanamide

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Technology Process of 4-cyclohexyl-3-hydroxy-2-methylene-N-phenyl-4-<(trimethylsilyl)oxy>butanamide

There total 6 articles about 4-cyclohexyl-3-hydroxy-2-methylene-N-phenyl-4-<(trimethylsilyl)oxy>butanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 103633-67-6
4-cyclohexyl-N-phenyl-2-<(phenylseleno)methyl>-4-<(trimethylsilyl)oxy>-2-butenamide

: 103633-69-8
4-cyclohexyl-3-hydroxy-2-methylene-N-phenyl-4-<(trimethylsilyl)oxy>butanamide

Guidance literature:: With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at -78 ℃; for 1h;
DOI:10.1016/S0040-4039(00)94941-4 DOI:10.1021/jo00262a020

Reference yield:

: 103633-61-0
4-cyclohexyl-4-hydroxy-2-methylene-N-phenyl-3-(phenylsulfonyl)butanamide

: 103633-69-8
4-cyclohexyl-3-hydroxy-2-methylene-N-phenyl-4-<(trimethylsilyl)oxy>butanamide

Guidance literature:: Multi-step reaction with 3 steps

1: 76 percent

2: 87 percent / NaBH₄ / ethanol; tetrahydrofuran / 2 h / Ambient temperature

3: 75 percent / MCPBA / CH₂Cl₂ / 1 h / -78 °C

With sodium tetrahydroborate; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1021/jo00262a020

Reference yield:

: 103633-64-3
4-cyclohexyl-2-methylene-N-phenyl-3-(phenylsulfonyl)-4-<(trimethylsilyl)oxy>butanamide

: 103633-69-8
4-cyclohexyl-3-hydroxy-2-methylene-N-phenyl-4-<(trimethylsilyl)oxy>butanamide

Guidance literature:: Multi-step reaction with 2 steps

1: 87 percent / NaBH₄ / ethanol; tetrahydrofuran / 2 h / Ambient temperature

2: 75 percent / MCPBA / CH₂Cl₂ / 1 h / -78 °C

With sodium tetrahydroborate; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1021/jo00262a020