4-Bromo-benzoic acid (5R,5aR,9aS)-5,5a-dihydroxy-2-isopropyl-9,9-dimethyl-5a,6,7,8,9,9a,10,11-octahydro-5H-dibenzo[a,d]cyclohepten-3-yl ester

Base Information

Chemical Name:4-Bromo-benzoic acid (5R,5aR,9aS)-5,5a-dihydroxy-2-isopropyl-9,9-dimethyl-5a,6,7,8,9,9a,10,11-octahydro-5H-dibenzo[a,d]cyclohepten-3-yl ester
CAS No.:95263-40-4
Molecular Formula:C₂₇H₃₃BrO₄
Molecular Weight:501.461
Hs Code.:

Synonyms:4-Bromo-benzoic acid (5R,5aR,9aS)-5,5a-dihydroxy-2-isopropyl-9,9-dimethyl-5a,6,7,8,9,9a,10,11-octahydro-5H-dibenzo[a,d]cyclohepten-3-yl ester

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Chemical Property of 4-Bromo-benzoic acid (5R,5aR,9aS)-5,5a-dihydroxy-2-isopropyl-9,9-dimethyl-5a,6,7,8,9,9a,10,11-octahydro-5H-dibenzo[a,d]cyclohepten-3-yl ester

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Technology Process of 4-Bromo-benzoic acid (5R,5aR,9aS)-5,5a-dihydroxy-2-isopropyl-9,9-dimethyl-5a,6,7,8,9,9a,10,11-octahydro-5H-dibenzo[a,d]cyclohepten-3-yl ester

There total 3 articles about 4-Bromo-benzoic acid (5R,5aR,9aS)-5,5a-dihydroxy-2-isopropyl-9,9-dimethyl-5a,6,7,8,9,9a,10,11-octahydro-5H-dibenzo[a,d]cyclohepten-3-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 106540-58-3
4-Bromo-benzoic acid (5aR,9aS)-5a-hydroxy-2-isopropyl-9,9-dimethyl-5-oxo-5a,6,7,8,9,9a,10,11-octahydro-5H-dibenzo[a,d]cyclohepten-3-yl ester

: 95263-40-4
4-Bromo-benzoic acid (5R,5aR,9aS)-5,5a-dihydroxy-2-isopropyl-9,9-dimethyl-5a,6,7,8,9,9a,10,11-octahydro-5H-dibenzo[a,d]cyclohepten-3-yl ester

Guidance literature:: With sodium tetrahydroborate; In methanol; at 0 ℃; for 2h;
DOI:10.1016/S0040-4020(01)87451-2

Reference yield:

: 95263-39-1
4-Bromo-benzoic acid (5S,5aR,9aS)-5,5a-dihydroxy-2-isopropyl-9,9-dimethyl-5a,6,7,8,9,9a,10,11-octahydro-5H-dibenzo[a,d]cyclohepten-3-yl ester

: 95263-40-4
4-Bromo-benzoic acid (5R,5aR,9aS)-5,5a-dihydroxy-2-isopropyl-9,9-dimethyl-5a,6,7,8,9,9a,10,11-octahydro-5H-dibenzo[a,d]cyclohepten-3-yl ester

Guidance literature:: Multi-step reaction with 2 steps

1: DMSO-Ac₂O

2: NaBH₄

With sodium tetrahydroborate; acetic anhydride; dimethyl sulfoxide;

Reference yield:

: 586-75-4
4-chlorobenzoyl chloride

: 95263-40-4
4-Bromo-benzoic acid (5R,5aR,9aS)-5,5a-dihydroxy-2-isopropyl-9,9-dimethyl-5a,6,7,8,9,9a,10,11-octahydro-5H-dibenzo[a,d]cyclohepten-3-yl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 2.4 mg / 4-dimethylaminopyridine / pyridine / 48 h / 40 °C

2: 1.5 mg / DMSO / acetic anhydride / 3 h / Ambient temperature

3: 1.1 mg / NaBH₄ / methanol / 2 h / 0 °C

With dmap; sodium tetrahydroborate; dimethyl sulfoxide; In pyridine; methanol; acetic anhydride;
DOI:10.1016/S0040-4020(01)87451-2