N-[2-[[[(4-fluoro-3-methylphenyl)methyl]amino]carbonyl]-6,7,8,9-tetrahydro-3-methoxy-4-oxo-7-(4H-1,2,4-triazol-3-yl)-7,10-ethanopyrimido[1,2-a]azepin-10(4H)-yl]-N₁,N₁-dimethyl-ethanediamide

Base Information

• Chemical Name: N-[2-[[[(4-fluoro-3-methylphenyl)methyl]amino]carbonyl]-6,7,8,9-tetrahydro-3-methoxy-4-oxo-7-(4H-1,2,4-triazol-3-yl)-7,10-ethanopyrimido[1,2-a]azepin-10(4H)-yl]-N₁,N₁-dimethyl-ethanediamide
• CAS No.: 1380665-31-5
• Molecular Formula: C₂₇H₃₁FN₈O₅
• Molecular Weight: 566.592

Synonyms:N-[2-[[[(4-fluoro-3-methylphenyl)methyl]amino]carbonyl]-6,7,8,9-tetrahydro-3-methoxy-4-oxo-7-(4H-1,2,4-triazol-3-yl)-7,10-ethanopyrimido[1,2-a]azepin-10(4H)-yl]-N₁,N₁-dimethyl-ethanediamide

Chemical Property of N-[2-[[[(4-fluoro-3-methylphenyl)methyl]amino]carbonyl]-6,7,8,9-tetrahydro-3-methoxy-4-oxo-7-(4H-1,2,4-triazol-3-yl)-7,10-ethanopyrimido[1,2-a]azepin-10(4H)-yl]-N₁,N₁-dimethyl-ethanediamide

Chemical Property:

Purity/Quality:

Safty Information:

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Useful:

Technology Process of N-[2-[[[(4-fluoro-3-methylphenyl)methyl]amino]carbonyl]-6,7,8,9-tetrahydro-3-methoxy-4-oxo-7-(4H-1,2,4-triazol-3-yl)-7,10-ethanopyrimido[1,2-a]azepin-10(4H)-yl]-N₁,N₁-dimethyl-ethanediamide

There total 6 articles about N-[2-[[[(4-fluoro-3-methylphenyl)methyl]amino]carbonyl]-6,7,8,9-tetrahydro-3-methoxy-4-oxo-7-(4H-1,2,4-triazol-3-yl)-7,10-ethanopyrimido[1,2-a]azepin-10(4H)-yl]-N₁,N₁-dimethyl-ethanediamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

10-[[2-(dimethylamino)-1,2-dioxoethyl]amino]-N7-[(1E)-(dimethylamino)methylene]-N2-[(4-fluoro-3-methylphenyl)methyl]-4,8,9,10-tetrahydro-3-methoxy-4-oxo-7,10-ethanopyrimido[1,2-a]azepine-2,7(6H)-dicarboxamide (1380665-30-4) → N-[2-[[[(4-fluoro-3-methylphenyl)methyl]amino]carbonyl]-6,7,8,9-tetrahydro-3-methoxy-4-oxo-7-(4H-1,2,4-triazol-3-yl)-7,10-ethanopyrimido[1,2-a]azepin-10(4H)-yl]-N1,N1-dimethyl-ethanediamide (1380665-31-5)

Guidance literature:

With hydrazinium monoacetate; acetic acid; at 80 ℃; for 2h;

Reference yield:

N-[7-[(acetyloxy)methyl]-2-[[[(4-fluoro-3-methylphenyl)methyl]amino]carbonyl]-6,7,8,9-tetrahydro-3-methoxy-4-oxo-7,10-ethanopyrimido[1,2-a]azepin-10(4H)-yl]-carbamic acid phenylmethyl ester (1380665-18-8) → N-[2-[[[(4-fluoro-3-methylphenyl)methyl]amino]carbonyl]-6,7,8,9-tetrahydro-3-methoxy-4-oxo-7-(4H-1,2,4-triazol-3-yl)-7,10-ethanopyrimido[1,2-a]azepin-10(4H)-yl]-N1,N1-dimethyl-ethanediamide (1380665-31-5)

Guidance literature:

Multi-step reaction with 8 steps

1: hydrogen / palladium 10% on activated carbon / methanol

2: 4-methyl-morpholine; HATU / 1 h

3: sodium carbonate / acetonitrile; water; methanol / 1 h

4: Dess-Martin periodane / dichloromethane

5: sodium chlorite; sodium dihydrogenphosphate / water; tert-butyl alcohol / 0.75 h

6: pyridine; di-tert-butyl dicarbonate; ammonium bicarbonate / 1,4-dioxane / 18 h

7: 2 h / 120 °C

8: hydrazinium monoacetate; acetic acid / 2 h / 80 °C

With 4-methyl-morpholine; pyridine; sodium chlorite; sodium dihydrogenphosphate; di-tert-butyl dicarbonate; hydrogen; hydrazinium monoacetate; sodium carbonate; ammonium bicarbonate; Dess-Martin periodane; acetic acid; HATU; palladium 10% on activated carbon; In 1,4-dioxane; methanol; dichloromethane; water; acetonitrile; tert-butyl alcohol;

Reference yield:

7-[(acetyloxy)methyl]-10-amino-N-[(4-fluoro-3-methylphenyl)methyl]-4,6,7,8,9,10-hexahydro-3-methoxy-4-oxo-7,10-ethanopyrimido[1,2-a]azepine-2-carboxamide (1380665-19-9) → N-[2-[[[(4-fluoro-3-methylphenyl)methyl]amino]carbonyl]-6,7,8,9-tetrahydro-3-methoxy-4-oxo-7-(4H-1,2,4-triazol-3-yl)-7,10-ethanopyrimido[1,2-a]azepin-10(4H)-yl]-N1,N1-dimethyl-ethanediamide (1380665-31-5)

Guidance literature:

Multi-step reaction with 7 steps

1: 4-methyl-morpholine; HATU / 1 h

2: sodium carbonate / acetonitrile; water; methanol / 1 h

3: Dess-Martin periodane / dichloromethane

4: sodium chlorite; sodium dihydrogenphosphate / water; tert-butyl alcohol / 0.75 h

5: pyridine; di-tert-butyl dicarbonate; ammonium bicarbonate / 1,4-dioxane / 18 h

6: 2 h / 120 °C

7: hydrazinium monoacetate; acetic acid / 2 h / 80 °C

With 4-methyl-morpholine; pyridine; sodium chlorite; sodium dihydrogenphosphate; di-tert-butyl dicarbonate; hydrazinium monoacetate; sodium carbonate; ammonium bicarbonate; Dess-Martin periodane; acetic acid; HATU; In 1,4-dioxane; methanol; dichloromethane; water; acetonitrile; tert-butyl alcohol;

upstream raw materials:

10-[[2-(dimethylamino)-1,2-dioxoethyl]amino]-N₂-[(4-fluoro-3-methylphenyl)methyl]-4,8,9,10-tetrahydro-3-methoxy-4-oxo-7,10-ethanopyrimido[1,2-a]azepine-2,7(6H)-dicarboxamide

10-[[2-(dimethylamino)-1,2-dioxoethyl]amino]-N₇-[(1E)-(dimethylamino)methylene]-N₂-[(4-fluoro-3-methylphenyl)methyl]-4,8,9,10-tetrahydro-3-methoxy-4-oxo-7,10-ethanopyrimido[1,2-a]azepine-2,7(6H)-dicarboxamide

N-[7-[(acetyloxy)methyl]-2-[[[(4-fluoro-3-methylphenyl)methyl]amino]carbonyl]-6,7,8,9-tetrahydro-3-methoxy-4-oxo-7,10-ethanopyrimido[1,2-a]azepin-10(4H)-yl]-carbamic acid phenylmethyl ester

7-[(acetyloxy)methyl]-10-amino-N-[(4-fluoro-3-methylphenyl)methyl]-4,6,7,8,9,10-hexahydro-3-methoxy-4-oxo-7,10-ethanopyrimido[1,2-a]azepine-2-carboxamide

Downstream raw materials:

N'-[2-[[[(4-fluoro-3-methylphenyl)methyl]amino]carbonyl]-6,7,8,9-tetrahydro-3-hydroxy-4-oxo-7-(1H-1,2,4-triazol-3-yl)-7,10-ethanopyrimido[1,2-a]azepin-10(4H)-yl]-N,N-dimethyl-ethanediamide

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