10-methyl-2-[2-(3,4,5-trifluoroanilino)-3-pyridyl]-5,10-dihydro-5λ6-benzo[e][1,2,4]triazolo[1,5-b][1,2,4]thiadiazine-5,5-dione

Base Information

Chemical Name:10-methyl-2-[2-(3,4,5-trifluoroanilino)-3-pyridyl]-5,10-dihydro-5λ6-benzo[e][1,2,4]triazolo[1,5-b][1,2,4]thiadiazine-5,5-dione
CAS No.:1350515-70-6
Molecular Formula:C₂₀H₁₃F₃N₆O₂S
Molecular Weight:458.423
Hs Code.:

Synonyms:10-methyl-2-[2-(3,4,5-trifluoroanilino)-3-pyridyl]-5,10-dihydro-5λ6-benzo[e][1,2,4]triazolo[1,5-b][1,2,4]thiadiazine-5,5-dione

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Chemical Property of 10-methyl-2-[2-(3,4,5-trifluoroanilino)-3-pyridyl]-5,10-dihydro-5λ6-benzo[e][1,2,4]triazolo[1,5-b][1,2,4]thiadiazine-5,5-dione

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Technology Process of 10-methyl-2-[2-(3,4,5-trifluoroanilino)-3-pyridyl]-5,10-dihydro-5λ6-benzo[e][1,2,4]triazolo[1,5-b][1,2,4]thiadiazine-5,5-dione

There total 4 articles about 10-methyl-2-[2-(3,4,5-trifluoroanilino)-3-pyridyl]-5,10-dihydro-5λ6-benzo[e][1,2,4]triazolo[1,5-b][1,2,4]thiadiazine-5,5-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 1350515-53-5
2-(3,4,5-trifluorophenylamino) nicotinic acid

: 107089-79-2
NSC 373858

: 1350515-70-6
10-methyl-2-[2-(3,4,5-trifluoroanilino)-3-pyridyl]-5,10-dihydro-5λ6-benzo[e][1,2,4]triazolo[1,5-b][1,2,4]thiadiazine-5,5-dione

Guidance literature:: With trichlorophosphate; at 105 ℃; Inert atmosphere;
DOI:10.1016/j.bmc.2011.09.060

Reference yield:

: 163733-96-8
3,4,5-trifluoro aniline

: 1350515-70-6
10-methyl-2-[2-(3,4,5-trifluoroanilino)-3-pyridyl]-5,10-dihydro-5λ6-benzo[e][1,2,4]triazolo[1,5-b][1,2,4]thiadiazine-5,5-dione

Guidance literature:: Multi-step reaction with 3 steps

1: ethylene glycol / 6 h / 160 °C

2: sodium hydroxide / ethanol / 2 h / Reflux

3: trichlorophosphate / 105 °C / Inert atmosphere

With sodium hydroxide; trichlorophosphate; In ethanol; ethylene glycol;
DOI:10.1016/j.bmc.2011.09.060

Reference yield:

: 1452-94-4
ethyl 2-chloronicotinate

: 1350515-70-6
10-methyl-2-[2-(3,4,5-trifluoroanilino)-3-pyridyl]-5,10-dihydro-5λ6-benzo[e][1,2,4]triazolo[1,5-b][1,2,4]thiadiazine-5,5-dione

Guidance literature:: Multi-step reaction with 3 steps

1: ethylene glycol / 6 h / 160 °C

2: sodium hydroxide / ethanol / 2 h / Reflux

3: trichlorophosphate / 105 °C / Inert atmosphere

With sodium hydroxide; trichlorophosphate; In ethanol; ethylene glycol;
DOI:10.1016/j.bmc.2011.09.060