Benzyl 4-[(tert-butoxycarbonyl)amino]-3-methoxy-1-methyl-1H-pyrrole-2-carboxylate

Base Information

Chemical Name:Benzyl 4-[(tert-butoxycarbonyl)amino]-3-methoxy-1-methyl-1H-pyrrole-2-carboxylate
CAS No.:285137-96-4
Molecular Formula:C₁₉H₂₄N₂O₅
Molecular Weight:360.41
Hs Code.:

Synonyms:Benzyl 4-[(tert-butoxycarbonyl)amino]-3-methoxy-1-methyl-1H-pyrrole-2-carboxylate

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Chemical Property of Benzyl 4-[(tert-butoxycarbonyl)amino]-3-methoxy-1-methyl-1H-pyrrole-2-carboxylate

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Technology Process of Benzyl 4-[(tert-butoxycarbonyl)amino]-3-methoxy-1-methyl-1H-pyrrole-2-carboxylate

There total 6 articles about Benzyl 4-[(tert-butoxycarbonyl)amino]-3-methoxy-1-methyl-1H-pyrrole-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 212184-26-4
Ethyl 4-[(tert-butoxycarbonyl)amino]-3-methoxy-1-methyl-1H-pyrrole-2-carboxylate

: 100-51-6,185532-71-2
benzyl alcohol

: 285137-96-4
Benzyl 4-[(tert-butoxycarbonyl)amino]-3-methoxy-1-methyl-1H-pyrrole-2-carboxylate

Guidance literature:: With sodium; at 100 ℃; for 1h; under 10 Torr;
DOI:10.1055/s-2000-6394

Reference yield:

: 65171-74-6
3-hydroxy-1-methyl-pyrrole-2,4-dicarboxylic acid diethyl ester

: 285137-96-4
Benzyl 4-[(tert-butoxycarbonyl)amino]-3-methoxy-1-methyl-1H-pyrrole-2-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1: 79 percent / Na / 4 h / 100 °C / 10 Torr

2: 88 percent / K₂CO₃ / acetone / 24 h / Heating

3: 100 percent / H₂ / 10 percent Pd/C / 37503 Torr

4: diphenylphosphoryl azide; Et₃N / acetonitrile / 2 h / 85 °C

5: acetonitrile / 17 h / 100 °C

6: 87 percent / Na / 1 h / 100 °C / 10 Torr

With diphenylphosphoranyl azide; hydrogen; sodium; potassium carbonate; triethylamine; palladium on activated charcoal; In acetone; acetonitrile; 1: Substitution / 2: Etherification / 3: Hydrogenolysis / 4: Rearrangement / 5: Addition / 6: Substitution;
DOI:10.1055/s-2000-6394

Reference yield:

: 285137-92-0
4-Benzyl 2-ethyl 1-methyl-3-hydroxy-1H-pyrrole-2,4-dicarboxylate

: 285137-96-4
Benzyl 4-[(tert-butoxycarbonyl)amino]-3-methoxy-1-methyl-1H-pyrrole-2-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: 88 percent / K₂CO₃ / acetone / 24 h / Heating

2: 100 percent / H₂ / 10 percent Pd/C / 37503 Torr

3: diphenylphosphoryl azide; Et₃N / acetonitrile / 2 h / 85 °C

4: acetonitrile / 17 h / 100 °C

5: 87 percent / Na / 1 h / 100 °C / 10 Torr

With diphenylphosphoranyl azide; hydrogen; sodium; potassium carbonate; triethylamine; palladium on activated charcoal; In acetone; acetonitrile; 1: Etherification / 2: Hydrogenolysis / 3: Rearrangement / 4: Addition / 5: Substitution;
DOI:10.1055/s-2000-6394