ethyl 4-chloro-7-hydroxy-3-methyl-1-[2-({[4-(trifluoromethoxy)phenyl]carbamoyl}amino)phenyl]-2,3-dihydro-1H-indole-3-carboxylate

Base Information

Chemical Name:ethyl 4-chloro-7-hydroxy-3-methyl-1-[2-({[4-(trifluoromethoxy)phenyl]carbamoyl}amino)phenyl]-2,3-dihydro-1H-indole-3-carboxylate
CAS No.:1555694-30-8
Molecular Formula:C₂₆H₂₃ClF₃N₃O₅
Molecular Weight:549.934
Hs Code.:

Synonyms:ethyl 4-chloro-7-hydroxy-3-methyl-1-[2-({[4-(trifluoromethoxy)phenyl]carbamoyl}amino)phenyl]-2,3-dihydro-1H-indole-3-carboxylate

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Chemical Property of ethyl 4-chloro-7-hydroxy-3-methyl-1-[2-({[4-(trifluoromethoxy)phenyl]carbamoyl}amino)phenyl]-2,3-dihydro-1H-indole-3-carboxylate

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Technology Process of ethyl 4-chloro-7-hydroxy-3-methyl-1-[2-({[4-(trifluoromethoxy)phenyl]carbamoyl}amino)phenyl]-2,3-dihydro-1H-indole-3-carboxylate

There total 6 articles about ethyl 4-chloro-7-hydroxy-3-methyl-1-[2-({[4-(trifluoromethoxy)phenyl]carbamoyl}amino)phenyl]-2,3-dihydro-1H-indole-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: 1555700-74-7
ethyl 4-chloro-7-methoxy-3-methyl-1-[2-({[4-(trifluoromethoxy)-phenyl]carbamoyl}amino)phenyl]-2,3-dihydro-1H-indole-3-carboxylate

: 1555694-30-8
ethyl 4-chloro-7-hydroxy-3-methyl-1-[2-({[4-(trifluoromethoxy)phenyl]carbamoyl}amino)phenyl]-2,3-dihydro-1H-indole-3-carboxylate

Guidance literature:: With boron trichloride; tetra-(n-butyl)ammonium iodide; In dichloromethane; at -78 - 20 ℃; for 16h; Inert atmosphere;

Reference yield:

: 1555700-01-0
ethyl 1-(2-aminophenyl)-4-chloro-7-methoxy-3-methyl-2,3-dihydro-1H-indole-3-carboxylate

: 1555694-30-8
ethyl 4-chloro-7-hydroxy-3-methyl-1-[2-({[4-(trifluoromethoxy)phenyl]carbamoyl}amino)phenyl]-2,3-dihydro-1H-indole-3-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: dichloromethane / 16 h / 20 °C

2: tetra-(n-butyl)ammonium iodide; boron trichloride / dichloromethane / 16 h / -78 - 20 °C / Inert atmosphere

With boron trichloride; tetra-(n-butyl)ammonium iodide; In dichloromethane;

Reference yield:

: 1555699-97-2
ethyl 4-chloro-7-methoxy-3-methyl-2,3-dihydro-1H-indole-3-carboxylate

: 1555694-30-8
ethyl 4-chloro-7-hydroxy-3-methyl-1-[2-({[4-(trifluoromethoxy)phenyl]carbamoyl}amino)phenyl]-2,3-dihydro-1H-indole-3-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate / toluene / 24 h / 85 - 110 °C / Inert atmosphere; Sealed tube

2: zinc; ammonium chloride / ethyl acetate; methanol / 1 h / 20 °C

3: dichloromethane / 16 h / 20 °C

4: tetra-(n-butyl)ammonium iodide; boron trichloride / dichloromethane / 16 h / -78 - 20 °C / Inert atmosphere

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; boron trichloride; tetra-(n-butyl)ammonium iodide; ammonium chloride; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; zinc; In methanol; dichloromethane; ethyl acetate; toluene;