2-chloro-3-(4-chlorophenoxy)-4-(trifluoromethyl)quinolin-6-yl(1-methyl-1H-imidazol-5-yl)(6-(trifluoromethyl)pyridin-3-yl)methanol

Base Information

Chemical Name:2-chloro-3-(4-chlorophenoxy)-4-(trifluoromethyl)quinolin-6-yl(1-methyl-1H-imidazol-5-yl)(6-(trifluoromethyl)pyridin-3-yl)methanol
CAS No.:1599525-28-6
Molecular Formula:C₂₇H₁₆Cl₂F₆N₄O₂
Molecular Weight:613.346
Hs Code.:

Synonyms:2-chloro-3-(4-chlorophenoxy)-4-(trifluoromethyl)quinolin-6-yl(1-methyl-1H-imidazol-5-yl)(6-(trifluoromethyl)pyridin-3-yl)methanol

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Chemical Property of 2-chloro-3-(4-chlorophenoxy)-4-(trifluoromethyl)quinolin-6-yl(1-methyl-1H-imidazol-5-yl)(6-(trifluoromethyl)pyridin-3-yl)methanol

Chemical Property:

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Technology Process of 2-chloro-3-(4-chlorophenoxy)-4-(trifluoromethyl)quinolin-6-yl(1-methyl-1H-imidazol-5-yl)(6-(trifluoromethyl)pyridin-3-yl)methanol

There total 8 articles about 2-chloro-3-(4-chlorophenoxy)-4-(trifluoromethyl)quinolin-6-yl(1-methyl-1H-imidazol-5-yl)(6-(trifluoromethyl)pyridin-3-yl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1599524-55-6
(1-methyl-1H-imidazol-5-yl)(6-(trifluoromethyl)pyridin-3-yl)methanone

: 1599524-66-9
6-bromo-2-chloro-3-(4-chlorophenoxy)-4-(trifluoromethyl)quinoline

: 1599525-28-6
2-chloro-3-(4-chlorophenoxy)-4-(trifluoromethyl)quinolin-6-yl(1-methyl-1H-imidazol-5-yl)(6-(trifluoromethyl)pyridin-3-yl)methanol

Guidance literature:: With trifluoroacetic acid; In ethyl acetate;

Reference yield:

: 460-00-4
1-Bromo-4-fluorobenzene

: 1599525-28-6
2-chloro-3-(4-chlorophenoxy)-4-(trifluoromethyl)quinolin-6-yl(1-methyl-1H-imidazol-5-yl)(6-(trifluoromethyl)pyridin-3-yl)methanol

Guidance literature:: Multi-step reaction with 5 steps

1: n-butyllithium; diisopropylamine / tetrahydrofuran; hexane

2: sodium azide; sodium sulfate / n-heptane; water; dimethyl sulfoxide

3: triethylamine / dichloromethane

4: N-ethyl-N,N-diisopropylamine / trichlorophosphate

5: trifluoroacetic acid / ethyl acetate

With n-butyllithium; sodium azide; sodium sulfate; triethylamine; diisopropylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; hexane; n-heptane; dichloromethane; water; dimethyl sulfoxide; ethyl acetate; trichlorophosphate;

Reference yield:

: 617706-15-7
1-(5-bromo-2-fluorophenyl)-2,2,2-trifluoro-ethanone

: 1599525-28-6
2-chloro-3-(4-chlorophenoxy)-4-(trifluoromethyl)quinolin-6-yl(1-methyl-1H-imidazol-5-yl)(6-(trifluoromethyl)pyridin-3-yl)methanol

Guidance literature:: Multi-step reaction with 4 steps

1: sodium azide; sodium sulfate / n-heptane; water; dimethyl sulfoxide

2: triethylamine / dichloromethane

3: N-ethyl-N,N-diisopropylamine / trichlorophosphate

4: trifluoroacetic acid / ethyl acetate

With sodium azide; sodium sulfate; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In n-heptane; dichloromethane; water; dimethyl sulfoxide; ethyl acetate; trichlorophosphate;