tert-butyl {[6-(3-cyanopropyl)-4-(4-methylphenyl)-2-(2-methylpropyl)quinolin-3-yl]methyl}carbamate

Base Information

Chemical Name:tert-butyl {[6-(3-cyanopropyl)-4-(4-methylphenyl)-2-(2-methylpropyl)quinolin-3-yl]methyl}carbamate
CAS No.:660452-08-4
Molecular Formula:C₃₀H₃₇N₃O₂
Molecular Weight:471.643
Hs Code.:

Synonyms:tert-butyl {[6-(3-cyanopropyl)-4-(4-methylphenyl)-2-(2-methylpropyl)quinolin-3-yl]methyl}carbamate

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Chemical Property of tert-butyl {[6-(3-cyanopropyl)-4-(4-methylphenyl)-2-(2-methylpropyl)quinolin-3-yl]methyl}carbamate

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Technology Process of tert-butyl {[6-(3-cyanopropyl)-4-(4-methylphenyl)-2-(2-methylpropyl)quinolin-3-yl]methyl}carbamate

There total 14 articles about tert-butyl {[6-(3-cyanopropyl)-4-(4-methylphenyl)-2-(2-methylpropyl)quinolin-3-yl]methyl}carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₉H₃₇ClN₂O₂

: 660452-08-4
tert-butyl {[6-(3-cyanopropyl)-4-(4-methylphenyl)-2-(2-methylpropyl)quinolin-3-yl]methyl}carbamate

Guidance literature:: With potassium cyanide; In dimethyl sulfoxide; at 60 ℃; for 2.5h;

Reference yield:

: 304854-54-4
2-amino-5-bromo-N-methoxy-N-methyl-benzamide

: 660452-08-4
tert-butyl {[6-(3-cyanopropyl)-4-(4-methylphenyl)-2-(2-methylpropyl)quinolin-3-yl]methyl}carbamate

Guidance literature:: Multi-step reaction with 8 steps

1: tetrahydrofuran; diethyl ether / 0.5 h / 0 °C

2: methanesulfonic acid / toluene / 17 h / Reflux

3: N-benzyl-N,N,N-triethylammonium chloride; palladium diacetate; triethylamine / N,N-dimethyl-formamide / 20 h / 70 °C

4: sodium tetrahydroborate / tetrahydrofuran; methanol / 0.17 h / 0 °C

5: ammonia; hydrogen / tetrahydrofuran; methanol / 3 h / 70 °C / 3750.38 Torr

6: tetrahydrofuran / 3 h / 20 °C

7: triethylamine / 0.5 h / 0 °C

8: dimethyl sulfoxide / 1.5 h / 60 °C

With sodium tetrahydroborate; methanesulfonic acid; N-benzyl-N,N,N-triethylammonium chloride; ammonia; hydrogen; palladium diacetate; triethylamine; In tetrahydrofuran; methanol; diethyl ether; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene; 3: Heck reaction;
DOI:10.1021/jm101236h

Reference yield:

: C₂₄H₃₀N₂O

: 660452-08-4
tert-butyl {[6-(3-cyanopropyl)-4-(4-methylphenyl)-2-(2-methylpropyl)quinolin-3-yl]methyl}carbamate

Guidance literature:: Multi-step reaction with 3 steps

1: tetrahydrofuran / 3 h / 20 °C

2: triethylamine / 0.5 h / 0 °C

3: dimethyl sulfoxide / 1.5 h / 60 °C

With triethylamine; In tetrahydrofuran; dimethyl sulfoxide;
DOI:10.1021/jm101236h