(S)-7-chloro-3-(3,5-dimethylphenyl)-6-nitro-4-(2-piperidin-2-yl-ethoxy)-1H-quinolin-2-one

Base Information

Chemical Name:(S)-7-chloro-3-(3,5-dimethylphenyl)-6-nitro-4-(2-piperidin-2-yl-ethoxy)-1H-quinolin-2-one
CAS No.:199940-73-3
Molecular Formula:C₂₄H₂₆ClN₃O₄
Molecular Weight:455.941
Hs Code.:

Synonyms:(S)-7-chloro-3-(3,5-dimethylphenyl)-6-nitro-4-(2-piperidin-2-yl-ethoxy)-1H-quinolin-2-one

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Chemical Property of (S)-7-chloro-3-(3,5-dimethylphenyl)-6-nitro-4-(2-piperidin-2-yl-ethoxy)-1H-quinolin-2-one

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Technology Process of (S)-7-chloro-3-(3,5-dimethylphenyl)-6-nitro-4-(2-piperidin-2-yl-ethoxy)-1H-quinolin-2-one

There total 13 articles about (S)-7-chloro-3-(3,5-dimethylphenyl)-6-nitro-4-(2-piperidin-2-yl-ethoxy)-1H-quinolin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 199942-73-9
(S)-2-{2-[7-chloro-3-(3,5-dimethylphenyl)-6-nitro-2-oxo-1,2-dihydroquinolin-4-yloxy]-ethyl}-piperidine-1-carboxylic acid tert-butyl ester

: 199940-73-3
(S)-7-chloro-3-(3,5-dimethylphenyl)-6-nitro-4-(2-piperidin-2-yl-ethoxy)-1H-quinolin-2-one

Guidance literature:: With methoxybenzene; trifluoroacetic acid; In dichloromethane; at 20 ℃; for 3h;
DOI:10.1016/S0960-894X(99)00447-3

Reference yield:

: 26250-84-0
(S)-(-)-1-(tert-butoxycarbonyl)-2-piperidinecarboxylic acid

: 199940-73-3
(S)-7-chloro-3-(3,5-dimethylphenyl)-6-nitro-4-(2-piperidin-2-yl-ethoxy)-1H-quinolin-2-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: Et₃N / tetrahydrofuran; diethyl ether / 1 h / 0 °C

2.1: diethyl ether / 3 h / 0 °C

2.2: AgOBz; Et₃N / 3 h / 0 - 20 °C

3.1: LiAlH₄ / diethyl ether / 0.5 h / 0 °C

4.1: PPh₃; diethylazodicarboxylate / tetrahydrofuran / 16 h / 20 °C

5.1: TFA; anisole / CH₂Cl₂ / 3 h / 20 °C

With lithium aluminium tetrahydride; methoxybenzene; triethylamine; triphenylphosphine; trifluoroacetic acid; diethylazodicarboxylate; In tetrahydrofuran; diethyl ether; dichloromethane; 1.1: Condensation / 2.1: Condensation / 2.2: Arndt-Eistert's reaction / 3.1: Reduction / 4.1: Alkylation / 5.1: deprotection;
DOI:10.1016/S0960-894X(99)00447-3

Reference yield:

: 199862-11-8
(S)-2-(diazoacetyl)piperidine-1-carboxylic acid tert-butyl ester

: 199940-73-3
(S)-7-chloro-3-(3,5-dimethylphenyl)-6-nitro-4-(2-piperidin-2-yl-ethoxy)-1H-quinolin-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: silver benzoate / methanol; ethyl acetate; triethylamine

2: sodium hydroxide / diethyl ether; water

3: triphenylphosphine / tetrahydrofuran

4: ammonium hydroxide; trifluoroacetic acid / methanol; tetrachloromethane; dichloromethane; chloroform; methoxybenzene

With ammonium hydroxide; sodium hydroxide; triphenylphosphine; trifluoroacetic acid; silver benzoate; In tetrahydrofuran; methanol; tetrachloromethane; diethyl ether; dichloromethane; chloroform; water; ethyl acetate; methoxybenzene; triethylamine;