7-bromo-6-(2-methyl-2H-[1,2,4]triazol-3-ylmethoxy)-3-phenyl-[1,2,4]triazolo[4,3-b]pyridazine

Base Information

• Chemical Name: 7-bromo-6-(2-methyl-2H-[1,2,4]triazol-3-ylmethoxy)-3-phenyl-[1,2,4]triazolo[4,3-b]pyridazine
• CAS No.: 262422-92-4
• Molecular Formula: C₁₅H₁₂BrN₇O
• Molecular Weight: 386.211

Synonyms:7-bromo-6-(2-methyl-2H-[1,2,4]triazol-3-ylmethoxy)-3-phenyl-[1,2,4]triazolo[4,3-b]pyridazine

Chemical Property of 7-bromo-6-(2-methyl-2H-[1,2,4]triazol-3-ylmethoxy)-3-phenyl-[1,2,4]triazolo[4,3-b]pyridazine

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Technology Process of 7-bromo-6-(2-methyl-2H-[1,2,4]triazol-3-ylmethoxy)-3-phenyl-[1,2,4]triazolo[4,3-b]pyridazine

There total 3 articles about 7-bromo-6-(2-methyl-2H-[1,2,4]triazol-3-ylmethoxy)-3-phenyl-[1,2,4]triazolo[4,3-b]pyridazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

1-methyl-1H-[1,2,4]-(triazol-5-yl)methanol (91616-36-3) + 7-bromo-6-chloro-3-phenyl-[1,2,4]triazolo[4,3-b]pyridazine (262422-91-3) → 7-bromo-6-(2-methyl-2H-[1,2,4]triazol-3-ylmethoxy)-3-phenyl-[1,2,4]triazolo[4,3-b]pyridazine (262422-92-4)

Guidance literature:

With potassium hexamethylsilazane; In tetrahydrofuran; at 0 ℃;

DOI:10.1016/S0040-4039(99)02153-X

Reference yield:

6-chloro-3-phenyl-7-trimethylsilanyl-[1,2,4]triazolo[4,3-b]pyridazine (262422-90-2) → 7-bromo-6-(2-methyl-2H-[1,2,4]triazol-3-ylmethoxy)-3-phenyl-[1,2,4]triazolo[4,3-b]pyridazine (262422-92-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 98 percent / (BrF₂C)2; [Bu₄N][Ph₃SnF₂] / tetrahydrofuran / 20 °C

2: 69 percent / KHMDS / tetrahydrofuran / 0 °C

With 1,2-dibromo-1,1,2,2-tetrafluoroethane; potassium hexamethylsilazane; tetrabutylammonium triphenyldifluorostannate; In tetrahydrofuran; 1: Substitution / 2: Substitution;

DOI:10.1016/S0040-4039(99)02153-X

Reference yield:

benzoic acid N'-(6-chloro-5-trimethylsilanyl-pyridazin-3-yl)-hydrazide (262422-89-9) → 7-bromo-6-(2-methyl-2H-[1,2,4]triazol-3-ylmethoxy)-3-phenyl-[1,2,4]triazolo[4,3-b]pyridazine (262422-92-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 97 percent / (BrCl₂C)2; PPh₃ / acetonitrile / 0 °C

2: 98 percent / (BrF₂C)2; [Bu₄N][Ph₃SnF₂] / tetrahydrofuran / 20 °C

3: 69 percent / KHMDS / tetrahydrofuran / 0 °C

With 1,2-dibromo-1,1,2,2-tetrachloroethane; 1,2-dibromo-1,1,2,2-tetrafluoroethane; potassium hexamethylsilazane; triphenylphosphine; tetrabutylammonium triphenyldifluorostannate; In tetrahydrofuran; acetonitrile; 1: Cyclization / 2: Substitution / 3: Substitution;

DOI:10.1016/S0040-4039(99)02153-X

upstream raw materials:

1-methyl-1H-[1,2,4]-(triazol-5-yl)methanol

7-bromo-6-chloro-3-phenyl-[1,2,4]triazolo[4,3-b]pyridazine

6-chloro-3-phenyl-7-trimethylsilanyl-[1,2,4]triazolo[4,3-b]pyridazine

benzoic acid N'-(6-chloro-5-trimethylsilanyl-pyridazin-3-yl)-hydrazide

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