(2R)-2-[2-fluoro-4-nitro(2,2,2-trifluoroethyl)anilino]-4-methyl-1-pentanol

Base Information

Chemical Name:(2R)-2-[2-fluoro-4-nitro(2,2,2-trifluoroethyl)anilino]-4-methyl-1-pentanol
CAS No.:329229-84-7
Molecular Formula:C₁₄H₁₈F₄N₂O₃
Molecular Weight:338.302
Hs Code.:

Synonyms:(2R)-2-[2-fluoro-4-nitro(2,2,2-trifluoroethyl)anilino]-4-methyl-1-pentanol

Suppliers and Price of (2R)-2-[2-fluoro-4-nitro(2,2,2-trifluoroethyl)anilino]-4-methyl-1-pentanol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R)-2-[2-fluoro-4-nitro(2,2,2-trifluoroethyl)anilino]-4-methyl-1-pentanol

Chemical Property:

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Technology Process of (2R)-2-[2-fluoro-4-nitro(2,2,2-trifluoroethyl)anilino]-4-methyl-1-pentanol

There total 4 articles about (2R)-2-[2-fluoro-4-nitro(2,2,2-trifluoroethyl)anilino]-4-methyl-1-pentanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 329229-82-5
(4R)-3-(2-Fluoro-4-nitrophenyl)-4-isobutyl-2-(trifluoromethyl)-1,3-oxazolidine

: 329229-84-7
(2R)-2-[2-fluoro-4-nitro(2,2,2-trifluoroethyl)anilino]-4-methyl-1-pentanol

Guidance literature:: With triethylsilane; boron trifluoride diethyl etherate; In chloroform; for 24h; Heating;
DOI:10.1021/jm061329j

Reference yield:

: 329229-80-3
(2R)-2-(2-fluoro-4-nitrophenyl)amino-4-methyl-1-pentanol

: 329229-84-7
(2R)-2-[2-fluoro-4-nitro(2,2,2-trifluoroethyl)anilino]-4-methyl-1-pentanol

Guidance literature:: Multi-step reaction with 2 steps

1: 65 percent / p-toluenesulfonic acid / benzene / Heating

2: 55 percent / Et₃SiH; BF₃*OEt₂ / CHCl₃ / 24 h / Heating

With triethylsilane; boron trifluoride diethyl etherate; toluene-4-sulfonic acid; In chloroform; benzene;
DOI:10.1021/jm061329j

Reference yield:

: 7533-40-6,16369-17-8,53448-09-2,502-32-9,14438-11-0
2-amino-4-methyl-1-pentanol

: 329229-84-7
(2R)-2-[2-fluoro-4-nitro(2,2,2-trifluoroethyl)anilino]-4-methyl-1-pentanol

Guidance literature:: Multi-step reaction with 3 steps

1: 55 percent / NaHCO₃ / ethanol / 16 h / Heating

2: 65 percent / p-toluenesulfonic acid / benzene / Heating

3: 55 percent / Et₃SiH; BF₃*OEt₂ / CHCl₃ / 24 h / Heating

With triethylsilane; boron trifluoride diethyl etherate; sodium hydrogencarbonate; toluene-4-sulfonic acid; In ethanol; chloroform; benzene;
DOI:10.1021/jm061329j