(RS)-(3-chloro-benzyl)-[3-(5-methoxy-3-methyl-3,6-dihydro-2H-[1,4]oxazin-3-yl)-phenyl]-amine

Base Information

Chemical Name:(RS)-(3-chloro-benzyl)-[3-(5-methoxy-3-methyl-3,6-dihydro-2H-[1,4]oxazin-3-yl)-phenyl]-amine
CAS No.:1386997-98-3
Molecular Formula:C₁₉H₂₁ClN₂O₂
Molecular Weight:344.841
Hs Code.:

Synonyms:(RS)-(3-chloro-benzyl)-[3-(5-methoxy-3-methyl-3,6-dihydro-2H-[1,4]oxazin-3-yl)-phenyl]-amine

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Chemical Property of (RS)-(3-chloro-benzyl)-[3-(5-methoxy-3-methyl-3,6-dihydro-2H-[1,4]oxazin-3-yl)-phenyl]-amine

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Technology Process of (RS)-(3-chloro-benzyl)-[3-(5-methoxy-3-methyl-3,6-dihydro-2H-[1,4]oxazin-3-yl)-phenyl]-amine

There total 8 articles about (RS)-(3-chloro-benzyl)-[3-(5-methoxy-3-methyl-3,6-dihydro-2H-[1,4]oxazin-3-yl)-phenyl]-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: 1266784-81-9
(RS)-3-(3-Bromo-phenyl)-5-methoxy-3-methyl-3,6-dihydro-2H [1,4]oxazine

: 4152-90-3
m-chlorobenzylamine

: 1386997-98-3
(RS)-(3-chloro-benzyl)-[3-(5-methoxy-3-methyl-3,6-dihydro-2H-[1,4]oxazin-3-yl)-phenyl]-amine

Guidance literature:: With sodium t-butanolate; tert-butyl XPhos; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; In toluene; at 100 ℃; for 15h; Inert atmosphere; Sealed vial;

Reference yield:

: 1183013-69-5
(RS)-2-amino-2-(3-bromo-phenyl)-propan-1-ol

: 1386997-98-3
(RS)-(3-chloro-benzyl)-[3-(5-methoxy-3-methyl-3,6-dihydro-2H-[1,4]oxazin-3-yl)-phenyl]-amine

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / acetonitrile / 2 h / -2 - 20 °C

2: potassium tert-butylate / tert-Amyl alcohol / 1 h / 20 - 30 °C

3: dichloromethane / 17 h / 20 °C / Inert atmosphere

4: sodium t-butanolate; tert-butyl XPhos / tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex / toluene / 15 h / 100 °C / Inert atmosphere; Sealed vial

With potassium tert-butylate; triethylamine; sodium t-butanolate; tert-butyl XPhos; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; In tert-Amyl alcohol; dichloromethane; toluene; acetonitrile;

Reference yield:

: 1262858-66-1
rac-N-[1-(3-bromophenyl)-2-hydroxy-1-methylethyl]-2-chloroacetamide

: 1386997-98-3
(RS)-(3-chloro-benzyl)-[3-(5-methoxy-3-methyl-3,6-dihydro-2H-[1,4]oxazin-3-yl)-phenyl]-amine

Guidance literature:: Multi-step reaction with 3 steps

1: potassium tert-butylate / tert-Amyl alcohol / 1 h / 20 - 30 °C

2: dichloromethane / 17 h / 20 °C / Inert atmosphere

3: sodium t-butanolate; tert-butyl XPhos / tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex / toluene / 15 h / 100 °C / Inert atmosphere; Sealed vial

With potassium tert-butylate; sodium t-butanolate; tert-butyl XPhos; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; In tert-Amyl alcohol; dichloromethane; toluene;