(4R,5R)-(+)-1-(2-(2-Hydroxy-3,4-dimethoxyphenyl)-ethyl)-5-ethyl-2-oxo-4-piperidineacetic Acid

Base Information

Chemical Name:(4R,5R)-(+)-1-(2-(2-Hydroxy-3,4-dimethoxyphenyl)-ethyl)-5-ethyl-2-oxo-4-piperidineacetic Acid
CAS No.:65929-07-9
Molecular Formula:C₁₉H₂₇NO₆
Molecular Weight:365.426
Hs Code.:

Synonyms:(4R,5R)-(+)-1-(2-(2-Hydroxy-3,4-dimethoxyphenyl)-ethyl)-5-ethyl-2-oxo-4-piperidineacetic Acid

Suppliers and Price of (4R,5R)-(+)-1-(2-(2-Hydroxy-3,4-dimethoxyphenyl)-ethyl)-5-ethyl-2-oxo-4-piperidineacetic Acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (4R,5R)-(+)-1-(2-(2-Hydroxy-3,4-dimethoxyphenyl)-ethyl)-5-ethyl-2-oxo-4-piperidineacetic Acid

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (4R,5R)-(+)-1-(2-(2-Hydroxy-3,4-dimethoxyphenyl)-ethyl)-5-ethyl-2-oxo-4-piperidineacetic Acid

There total 7 articles about (4R,5R)-(+)-1-(2-(2-Hydroxy-3,4-dimethoxyphenyl)-ethyl)-5-ethyl-2-oxo-4-piperidineacetic Acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 57103-66-9,57103-67-0,89709-06-8
{(R)-1-[2-(2-Benzyloxy-3,4-dimethoxy-phenyl)-ethyl]-5-ethyl-2-oxo-piperidin-4-yl}-acetic acid

: 65929-06-8,65929-07-9,73173-72-5
{(R)-5-Ethyl-1-[2-(2-hydroxy-3,4-dimethoxy-phenyl)-ethyl]-2-oxo-piperidin-4-yl}-acetic acid

Guidance literature:: With hydrogen; palladium on activated charcoal; for 4h; Ambient temperature;
DOI:10.1248/cpb.33.1716

Reference yield: 73.0%

: 65929-06-8
(4S,5R)-(-)-1-(2-(2-Hydroxy-3,4-dimethoxyphenyl)-ethyl)-5-ethyl-2-oxo-4-piperidineacetic Acid

: 65929-07-9
(4R,5R)-(+)-1-(2-(2-Hydroxy-3,4-dimethoxyphenyl)-ethyl)-5-ethyl-2-oxo-4-piperidineacetic Acid

Guidance literature:: at 180 ℃; for 1.5h;
DOI:10.1021/jo01298a025

Reference yield:

: 57103-66-9
(4S,5R)-(-)-1-(2-(2-Benzyloxy-3,4-dimethoxyphenyl)-ethyl)-5-ethyl-2-oxo-4-piperidineacetic Acid

: 65929-07-9
(4R,5R)-(+)-1-(2-(2-Hydroxy-3,4-dimethoxyphenyl)-ethyl)-5-ethyl-2-oxo-4-piperidineacetic Acid

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) aq. KOH; 2.) HCl / 1.) aq. EtOH, reflux, 96 h

2: 98 percent / H₂ / Pd-C (10percent) / 4 h / Ambient temperature

With hydrogenchloride; potassium hydroxide; hydrogen; palladium on activated charcoal;
DOI:10.1248/cpb.33.1716