3-({2-(2-fluoropyridin-3-yl)-4-[(methylamino)methyl]-1H-pyrrol-1-yl}sulfonyl)benzonitrile fumarate

Base Information

Chemical Name:3-({2-(2-fluoropyridin-3-yl)-4-[(methylamino)methyl]-1H-pyrrol-1-yl}sulfonyl)benzonitrile fumarate
CAS No.:1055305-00-4
Molecular Formula:C₄H₄O₄*C₁₈H₁₅FN₄O₂S
Molecular Weight:486.48
Hs Code.:

Synonyms:3-({2-(2-fluoropyridin-3-yl)-4-[(methylamino)methyl]-1H-pyrrol-1-yl}sulfonyl)benzonitrile fumarate

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Chemical Property of 3-({2-(2-fluoropyridin-3-yl)-4-[(methylamino)methyl]-1H-pyrrol-1-yl}sulfonyl)benzonitrile fumarate

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Technology Process of 3-({2-(2-fluoropyridin-3-yl)-4-[(methylamino)methyl]-1H-pyrrol-1-yl}sulfonyl)benzonitrile fumarate

There total 5 articles about 3-({2-(2-fluoropyridin-3-yl)-4-[(methylamino)methyl]-1H-pyrrol-1-yl}sulfonyl)benzonitrile fumarate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

: 1055306-47-2
tert-butyl ({1-[(3-cyanophenyl)sulfonyl]-5-(2-fluoropyridin-3-yl)-1H-pyrrol-3-yl}methyl)methylcarbamate

: 110-17-8,26099-09-2
(2E)-but-2-enedioic acid

: 1055305-00-4
3-({2-(2-fluoropyridin-3-yl)-4-[(methylamino)methyl]-1H-pyrrol-1-yl}sulfonyl)benzonitrile fumarate

Guidance literature:: tert-butyl ({1-[(3-cyanophenyl)sulfonyl]-5-(2-fluoropyridin-3-yl)-1H-pyrrol-3-yl}methyl)methylcarbamate; With hydrogenchloride; In methanol; water; ethyl acetate; at 20 ℃; for 2h;

(2E)-but-2-enedioic acid; In methanol; ethyl acetate;
DOI:10.1016/j.bmc.2017.04.014

Reference yield: 44.0%

: 1055305-00-4
3-({2-(2-fluoropyridin-3-yl)-4-[(methylamino)methyl]-1H-pyrrol-1-yl}sulfonyl)benzonitrile fumarate

Guidance literature:

Reference yield:

: 881678-18-8
tert-butyl {[5-bromo-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl]methyl}methylcarbamate

: 1055305-00-4
3-({2-(2-fluoropyridin-3-yl)-4-[(methylamino)methyl]-1H-pyrrol-1-yl}sulfonyl)benzonitrile fumarate

Guidance literature:: Multi-step reaction with 4 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / 1,2-dimethoxyethane; water / 3 h / 105 °C

2.1: sodium hydroxide / methanol; tetrahydrofuran / 4 h / 20 °C / Cooling with ice

3.1: sodium hydride / tetrahydrofuran; hexane / 0.5 h / 0 °C

3.2: 1 h / 0 - 20 °C

4.1: hydrogenchloride / water; methanol; ethyl acetate / 2 h / 20 °C

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydride; sodium carbonate; sodium hydroxide; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; hexane; water; ethyl acetate;
DOI:10.1016/j.bmc.2017.04.014