2-(benzylamino)-5,7-dimethoxytetralin

Base Information

Chemical Name:2-(benzylamino)-5,7-dimethoxytetralin
CAS No.:75903-09-2
Molecular Formula:C₁₉H₂₃NO₂
Molecular Weight:297.397
Hs Code.:

Synonyms:2-(benzylamino)-5,7-dimethoxytetralin

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Chemical Property of 2-(benzylamino)-5,7-dimethoxytetralin

Chemical Property:

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Technology Process of 2-(benzylamino)-5,7-dimethoxytetralin

There total 11 articles about 2-(benzylamino)-5,7-dimethoxytetralin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 75887-71-7
3-(3,5-Dimethoxy-benzyl)-dihydro-furan-2,5-dione

: 75903-09-2
2-(benzylamino)-5,7-dimethoxytetralin

Guidance literature:: Multi-step reaction with 8 steps

1: HF, pyridine

2: 96 percent / H₂ / 5percent Pd/C / acetic acid; H₂O / 2585.7 Torr

3: ethyl chloroformate, Et₃N / acetone / 2 h / -5 °C

4: NaN₃ / acetone; H₂O / 2 h / 0 °C

5: benzene / Heating

6: benzene / Heating

7: 92 percent / H₂ / 5percent Pd/C / acetic acid; H₂O / 12 h / 2585.7 Torr

8: 1.) p-toluenesulfonic acid, 2.) NaCNBH₃, glacial AcOH / 1.) benzene, 12 h, 2.) pH 6, MeOH, overnight

With pyridine; sodium azide; hydrogen fluoride; hydrogen; chloroformic acid ethyl ester; sodium cyanoborohydride; toluene-4-sulfonic acid; acetic acid; triethylamine; palladium on activated charcoal; In water; acetic acid; acetone; benzene;
DOI:10.1021/jm00134a005

Reference yield:

: 877-88-3
3,5-dimethoxybenzyl bromide

: 75903-09-2
2-(benzylamino)-5,7-dimethoxytetralin

Guidance literature:: Multi-step reaction with 12 steps

1: 1.) NaH / 1.) benzene, 25 deg C, 6 h, 2.) benzene, reflux

2: 86 percent / aq. NaOH / 72 h / Heating

3: 92 percent / 180 - 185 °C

4: Ac₂O / 4 h / 70 °C

5: HF, pyridine

6: 96 percent / H₂ / 5percent Pd/C / acetic acid; H₂O / 2585.7 Torr

7: ethyl chloroformate, Et₃N / acetone / 2 h / -5 °C

8: NaN₃ / acetone; H₂O / 2 h / 0 °C

9: benzene / Heating

10: benzene / Heating

11: 92 percent / H₂ / 5percent Pd/C / acetic acid; H₂O / 12 h / 2585.7 Torr

12: 1.) p-toluenesulfonic acid, 2.) NaCNBH₃, glacial AcOH / 1.) benzene, 12 h, 2.) pH 6, MeOH, overnight

With pyridine; sodium hydroxide; sodium azide; hydrogen fluoride; hydrogen; chloroformic acid ethyl ester; acetic anhydride; sodium hydride; sodium cyanoborohydride; toluene-4-sulfonic acid; acetic acid; triethylamine; palladium on activated charcoal; In water; acetic acid; acetone; benzene;
DOI:10.1021/jm00134a005

Reference yield:

: 70489-34-8
3-(3,5-dimethoxyphenyl)-1,2,2-propanetricarboxylic acid

: 75903-09-2
2-(benzylamino)-5,7-dimethoxytetralin

Guidance literature:: Multi-step reaction with 10 steps

1: 92 percent / 180 - 185 °C

2: Ac₂O / 4 h / 70 °C

3: HF, pyridine

4: 96 percent / H₂ / 5percent Pd/C / acetic acid; H₂O / 2585.7 Torr

5: ethyl chloroformate, Et₃N / acetone / 2 h / -5 °C

6: NaN₃ / acetone; H₂O / 2 h / 0 °C

7: benzene / Heating

8: benzene / Heating

9: 92 percent / H₂ / 5percent Pd/C / acetic acid; H₂O / 12 h / 2585.7 Torr

10: 1.) p-toluenesulfonic acid, 2.) NaCNBH₃, glacial AcOH / 1.) benzene, 12 h, 2.) pH 6, MeOH, overnight

With pyridine; sodium azide; hydrogen fluoride; hydrogen; chloroformic acid ethyl ester; acetic anhydride; sodium cyanoborohydride; toluene-4-sulfonic acid; acetic acid; triethylamine; palladium on activated charcoal; In water; acetic acid; acetone; benzene;
DOI:10.1021/jm00134a005