[(1S,2R,3S)-1-(3-Azido-propyl)-2-benzyloxy-3,4-dihydroxy-butyl]-carbamic acid tert-butyl ester

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Chemical Name:[(1S,2R,3S)-1-(3-Azido-propyl)-2-benzyloxy-3,4-dihydroxy-butyl]-carbamic acid tert-butyl ester
CAS No.:914402-53-2
Molecular Formula:C₁₉H₃₀N₄O₅
Molecular Weight:394.471
Hs Code.:

Synonyms:[(1S,2R,3S)-1-(3-Azido-propyl)-2-benzyloxy-3,4-dihydroxy-butyl]-carbamic acid tert-butyl ester

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Chemical Property of [(1S,2R,3S)-1-(3-Azido-propyl)-2-benzyloxy-3,4-dihydroxy-butyl]-carbamic acid tert-butyl ester

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Technology Process of [(1S,2R,3S)-1-(3-Azido-propyl)-2-benzyloxy-3,4-dihydroxy-butyl]-carbamic acid tert-butyl ester

There total 8 articles about [(1S,2R,3S)-1-(3-Azido-propyl)-2-benzyloxy-3,4-dihydroxy-butyl]-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 914402-52-1
{(S)-4-Azido-1-[(R)-benzyloxy-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-methyl]-butyl}-carbamic acid tert-butyl ester

: 914402-53-2
[(1S,2R,3S)-1-(3-Azido-propyl)-2-benzyloxy-3,4-dihydroxy-butyl]-carbamic acid tert-butyl ester

Guidance literature:: With sulfuric acid; In methanol;
DOI:10.1016/j.tetlet.2006.08.026

Reference yield:

: (R)-1-Benzyloxy-1-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-pent-4-en-2-ol

: 914402-53-2
[(1S,2R,3S)-1-(3-Azido-propyl)-2-benzyloxy-3,4-dihydroxy-butyl]-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: TEA / CH₂Cl₂

2.1: 85 percent / NaN₃ / dimethylformamide / 80 °C

3.1: LiAlH₄ / tetrahydrofuran / 0 °C

3.2: 90 percent / NaOH / tetrahydrofuran / 0 °C

4.1: 80 percent / BH₃-DMS; NaOH; H₂O₂ / tetrahydrofuran / 0 °C

5.1: TsCl; TEA / CH₂Cl₂

5.2: 85 percent / NaN₃ / dimethylformamide / 80 °C

6.1: 90 percent / H₂SO₄ / methanol

With sodium hydroxide; lithium aluminium tetrahydride; sodium azide; dimethylsulfide borane complex; TEA; sulfuric acid; dihydrogen peroxide; p-toluenesulfonyl chloride; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.tetlet.2006.08.026

Reference yield:

: 914402-56-5
(S)-4-((1R,2S)-2-Azido-1-benzyloxy-pent-4-enyl)-2,2-dimethyl-[1,3]dioxolane

: 914402-53-2
[(1S,2R,3S)-1-(3-Azido-propyl)-2-benzyloxy-3,4-dihydroxy-butyl]-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: LiAlH₄ / tetrahydrofuran / 0 °C

1.2: 90 percent / NaOH / tetrahydrofuran / 0 °C

2.1: 80 percent / BH₃-DMS; NaOH; H₂O₂ / tetrahydrofuran / 0 °C

3.1: TsCl; TEA / CH₂Cl₂

3.2: 85 percent / NaN₃ / dimethylformamide / 80 °C

4.1: 90 percent / H₂SO₄ / methanol

With sodium hydroxide; lithium aluminium tetrahydride; dimethylsulfide borane complex; TEA; sulfuric acid; dihydrogen peroxide; p-toluenesulfonyl chloride; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1016/j.tetlet.2006.08.026