ethyl 2-(((3R,5R,6S)-1-((S)-2-(tert-butylsulfonyl)-1-cyclopropylethyl)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxopiperidin-3-yl)-methyl)thiazole-5-carboxylate

Base Information

Chemical Name:ethyl 2-(((3R,5R,6S)-1-((S)-2-(tert-butylsulfonyl)-1-cyclopropylethyl)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxopiperidin-3-yl)-methyl)thiazole-5-carboxylate
CAS No.:1584732-10-4
Molecular Formula:C₃₄H₄₀Cl₂N₂O₅S₂
Molecular Weight:691.74
Hs Code.:

ethyl 2-(((3R,5R,6S)-1-((S)-2-(tert-butylsulfonyl)-1-cyclopropylethyl)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxopiperidin-3-yl)-methyl)thiazole-5-carboxylate

Synonyms:ethyl 2-(((3R,5R,6S)-1-((S)-2-(tert-butylsulfonyl)-1-cyclopropylethyl)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxopiperidin-3-yl)-methyl)thiazole-5-carboxylate

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Chemical Property of ethyl 2-(((3R,5R,6S)-1-((S)-2-(tert-butylsulfonyl)-1-cyclopropylethyl)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxopiperidin-3-yl)-methyl)thiazole-5-carboxylate

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Technology Process of ethyl 2-(((3R,5R,6S)-1-((S)-2-(tert-butylsulfonyl)-1-cyclopropylethyl)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxopiperidin-3-yl)-methyl)thiazole-5-carboxylate

There total 4 articles about ethyl 2-(((3R,5R,6S)-1-((S)-2-(tert-butylsulfonyl)-1-cyclopropylethyl)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxopiperidin-3-yl)-methyl)thiazole-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 2-((3R,5R,6S)-1-((S)-2-(tert-butylsulfonyl)-1-cyclopropylethyl)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxopiperidin-3-yl)ethanethioamide

: 33142-21-1
ethyl 2-chloro-3-oxopropanoate

: 1584732-10-4
ethyl 2-(((3R,5R,6S)-1-((S)-2-(tert-butylsulfonyl)-1-cyclopropylethyl)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxopiperidin-3-yl)-methyl)thiazole-5-carboxylate

Guidance literature:: In toluene; at 100 ℃; for 5h; Inert atmosphere; Microwave irradiation;
DOI:10.1021/jm401911v

Reference yield:

: 1584731-78-1
2-((3R,5R,6S)-1-((S)-2-(tert-butylsulfonyl)-1-cyclopropylethyl)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxopiperidin-3-yl)acetonitrile

: 1584732-10-4
ethyl 2-(((3R,5R,6S)-1-((S)-2-(tert-butylsulfonyl)-1-cyclopropylethyl)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxopiperidin-3-yl)-methyl)thiazole-5-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: tetraphosphorus decasulfide / ethanol / 12 h / Inert atmosphere; Heating

2: toluene / 5 h / 100 °C / Inert atmosphere; Microwave irradiation

With tetraphosphorus decasulfide; In ethanol; toluene;
DOI:10.1021/jm401911v

Reference yield:

: 1352066-57-9
2-((3R,5R,6S)-1-((S)-2-(tert-butylsulfonyl)-1-cyclopropylethyl)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxopiperidin-3-yl)acetic acid

: 1584732-10-4
ethyl 2-(((3R,5R,6S)-1-((S)-2-(tert-butylsulfonyl)-1-cyclopropylethyl)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxopiperidin-3-yl)-methyl)thiazole-5-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: ammonia; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide; methanol / 1 h / 40 °C / Inert atmosphere

2: triethylamine; trifluoroacetic anhydride / tetrahydrofuran / 0 °C / Inert atmosphere

3: tetraphosphorus decasulfide / ethanol / 12 h / Inert atmosphere; Heating

4: toluene / 5 h / 100 °C / Inert atmosphere; Microwave irradiation

With tetraphosphorus decasulfide; ammonia; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic anhydride; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In tetrahydrofuran; methanol; ethanol; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm401911v