(R)-1-(2-oxo-2-(4-phenoxyphenyl)ethyl)-3-((R)-2-phenyl-2-(phenylamino)acetoxy)-1-azoniabicyclo[2.2.2]octane 2,2,2-trifluoroacetate

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Chemical Name:(R)-1-(2-oxo-2-(4-phenoxyphenyl)ethyl)-3-((R)-2-phenyl-2-(phenylamino)acetoxy)-1-azoniabicyclo[2.2.2]octane 2,2,2-trifluoroacetate
CAS No.:1352633-51-2
Molecular Formula:C₂F₃O₂*C₃₅H₃₅N₂O₄
Molecular Weight:660.69
Hs Code.:

Synonyms:(R)-1-(2-oxo-2-(4-phenoxyphenyl)ethyl)-3-((R)-2-phenyl-2-(phenylamino)acetoxy)-1-azoniabicyclo[2.2.2]octane 2,2,2-trifluoroacetate

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Chemical Property of (R)-1-(2-oxo-2-(4-phenoxyphenyl)ethyl)-3-((R)-2-phenyl-2-(phenylamino)acetoxy)-1-azoniabicyclo[2.2.2]octane 2,2,2-trifluoroacetate

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Technology Process of (R)-1-(2-oxo-2-(4-phenoxyphenyl)ethyl)-3-((R)-2-phenyl-2-(phenylamino)acetoxy)-1-azoniabicyclo[2.2.2]octane 2,2,2-trifluoroacetate

There total 5 articles about (R)-1-(2-oxo-2-(4-phenoxyphenyl)ethyl)-3-((R)-2-phenyl-2-(phenylamino)acetoxy)-1-azoniabicyclo[2.2.2]octane 2,2,2-trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.4%

: 1233329-45-7
(R)-((R)-quinuclidin-3-yl) 2-phenyl-2-(phenylamino)-acetate

: 28179-33-1
4-(phenoxy)phenacyl bromide

: 1352633-51-2
(R)-1-(2-oxo-2-(4-phenoxyphenyl)ethyl)-3-((R)-2-phenyl-2-(phenylamino)acetoxy)-1-azoniabicyclo[2.2.2]octane 2,2,2-trifluoroacetate

Guidance literature:: With I₂; In ethyl acetate;

Reference yield: 36.4%

: 1233329-45-7
(R)-((R)-quinuclidin-3-yl) 2-phenyl-2-(phenylamino)-acetate

: 28179-33-1
4-(phenoxy)phenacyl bromide

: 76-05-1
trifluoroacetic acid

: 1352633-51-2
(R)-1-(2-oxo-2-(4-phenoxyphenyl)ethyl)-3-((R)-2-phenyl-2-(phenylamino)acetoxy)-1-azoniabicyclo[2.2.2]octane 2,2,2-trifluoroacetate

Guidance literature:: (R)-((R)-quinuclidin-3-yl) 2-phenyl-2-(phenylamino)-acetate; 4-(phenoxy)phenacyl bromide; In ethyl acetate; at 20 ℃; for 15h;

trifluoroacetic acid;

Reference yield:

: 62-53-3
aniline

: 1352633-51-2
(R)-1-(2-oxo-2-(4-phenoxyphenyl)ethyl)-3-((R)-2-phenyl-2-(phenylamino)acetoxy)-1-azoniabicyclo[2.2.2]octane 2,2,2-trifluoroacetate

Guidance literature:: Multi-step reaction with 3 steps

1: 0.08 h / 120 °C / microwave irradiation

2: dicyclohexyl-carbodiimide; benzotriazol-1-ol / tetrahydrofuran / 16 h / 20 °C

3: ethyl acetate / 15 h / 20 °C

With benzotriazol-1-ol; dicyclohexyl-carbodiimide; In tetrahydrofuran; ethyl acetate;