4-benzoyl-5-(4-bromophenyl)-1-(2-methoxy-4-(trifluoromethyl)phenyl)-3-((R)-1-phenylethylamino)-1H-pyrrol-2(5H)-one

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Chemical Name:4-benzoyl-5-(4-bromophenyl)-1-(2-methoxy-4-(trifluoromethyl)phenyl)-3-((R)-1-phenylethylamino)-1H-pyrrol-2(5H)-one
CAS No.:1610599-87-5
Molecular Formula:C₃₄H₂₈BrF₃N₂O₃
Molecular Weight:649.507
Hs Code.:

Synonyms:4-benzoyl-5-(4-bromophenyl)-1-(2-methoxy-4-(trifluoromethyl)phenyl)-3-((R)-1-phenylethylamino)-1H-pyrrol-2(5H)-one

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Chemical Property of 4-benzoyl-5-(4-bromophenyl)-1-(2-methoxy-4-(trifluoromethyl)phenyl)-3-((R)-1-phenylethylamino)-1H-pyrrol-2(5H)-one

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Technology Process of 4-benzoyl-5-(4-bromophenyl)-1-(2-methoxy-4-(trifluoromethyl)phenyl)-3-((R)-1-phenylethylamino)-1H-pyrrol-2(5H)-one

There total 4 articles about 4-benzoyl-5-(4-bromophenyl)-1-(2-methoxy-4-(trifluoromethyl)phenyl)-3-((R)-1-phenylethylamino)-1H-pyrrol-2(5H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 14.0%

: 3886-69-9
(R)-1-phenyl-ethyl-amine

: 1610600-04-8
C₂₆H₁₉BrF₃NO₄

: 1610599-87-5
4-benzoyl-5-(4-bromophenyl)-1-(2-methoxy-4-(trifluoromethyl)phenyl)-3-((R)-1-phenylethylamino)-1H-pyrrol-2(5H)-one

Guidance literature:: In acetic acid; at 120 ℃; for 2h; Microwave irradiation;
DOI:10.1016/j.bmcl.2014.04.063

Reference yield:

: 146070-34-0
2-fluoro-4-(trifluoromethyl)benzonitrile

: 1610599-87-5
4-benzoyl-5-(4-bromophenyl)-1-(2-methoxy-4-(trifluoromethyl)phenyl)-3-((R)-1-phenylethylamino)-1H-pyrrol-2(5H)-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / 12 h / 0 - 20 °C

2.1: lithium aluminium tetrahydride / 12 h / 0 - 20 °C

3.1: 1,4-dioxane / 0.17 h / 20 °C

3.2: 12 h

4.1: acetic acid / 2 h / 120 °C / Microwave irradiation

With lithium aluminium tetrahydride; sodium hydride; In 1,4-dioxane; acetic acid;
DOI:10.1016/j.bmcl.2014.04.063

Reference yield:

: 132927-08-3
2-methoxy-4-trifluoromethyl-benzonitrile

: 1610599-87-5
4-benzoyl-5-(4-bromophenyl)-1-(2-methoxy-4-(trifluoromethyl)phenyl)-3-((R)-1-phenylethylamino)-1H-pyrrol-2(5H)-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium aluminium tetrahydride / 12 h / 0 - 20 °C

2.1: 1,4-dioxane / 0.17 h / 20 °C

2.2: 12 h

3.1: acetic acid / 2 h / 120 °C / Microwave irradiation

With lithium aluminium tetrahydride; In 1,4-dioxane; acetic acid;
DOI:10.1016/j.bmcl.2014.04.063