Technology Process of 1-O-(α-D-galactopyranosyl)-2-(11-(3,4-dichlorophenyl)undecanoyl)amino-D-ribo-1,3,4-octadecanetriol
There total 11 articles about 1-O-(α-D-galactopyranosyl)-2-(11-(3,4-dichlorophenyl)undecanoyl)amino-D-ribo-1,3,4-octadecanetriol which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
4-methyl-morpholine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate;
In
methanol; dichloromethane;
at 20 ℃;
for 12h;
- Guidance literature:
-
Multi-step reaction with 7 steps
1: triflic azide; potassium carbonate; copper(II) sulfate / methanol; dichloromethane; water / 12 h / 0 - 20 °C
2: triethylamine / toluene / 21 h / 50 - 55 °C
3: sodium hydride / N,N-dimethyl-formamide; toluene / 18 h / 50 - 60 °C
4: hydrogenchloride / methanol; water; toluene / 20 h / 50 - 60 °C
5: Dimethyldisulphide; trifluoromethylsulfonic anhydride / tetrahydrofuran / 0.33 h / -10 °C / Molecular sieve
6: hydrogen; palladium(II) hydroxide / methanol; dichloromethane; acetic acid / 16 h / 20 °C / 4125.41 Torr
7: 4-methyl-morpholine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / methanol; dichloromethane / 12 h / 20 °C
With
4-methyl-morpholine; hydrogenchloride; Dimethyldisulphide; trifluoromethylsulfonic anhydride; triflic azide; hydrogen; palladium(II) hydroxide; sodium hydride; potassium carbonate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; copper(II) sulfate; triethylamine;
In
tetrahydrofuran; methanol; dichloromethane; water; acetic acid; N,N-dimethyl-formamide; toluene;
DOI:10.1002/cbic.201200004
- Guidance literature:
-
Multi-step reaction with 6 steps
1: triethylamine / toluene / 21 h / 50 - 55 °C
2: sodium hydride / N,N-dimethyl-formamide; toluene / 18 h / 50 - 60 °C
3: hydrogenchloride / methanol; water; toluene / 20 h / 50 - 60 °C
4: Dimethyldisulphide; trifluoromethylsulfonic anhydride / tetrahydrofuran / 0.33 h / -10 °C / Molecular sieve
5: hydrogen; palladium(II) hydroxide / methanol; dichloromethane; acetic acid / 16 h / 20 °C / 4125.41 Torr
6: 4-methyl-morpholine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / methanol; dichloromethane / 12 h / 20 °C
With
4-methyl-morpholine; hydrogenchloride; Dimethyldisulphide; trifluoromethylsulfonic anhydride; hydrogen; palladium(II) hydroxide; sodium hydride; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine;
In
tetrahydrofuran; methanol; dichloromethane; water; acetic acid; N,N-dimethyl-formamide; toluene;
DOI:10.1002/cbic.201200004
