3,3-bis(trifluoromethyl)-1-chloro-1,1-bis(p-methylphenyl)-3H-2,1-benzoxabismole

Base Information

• Chemical Name: 3,3-bis(trifluoromethyl)-1-chloro-1,1-bis(p-methylphenyl)-3H-2,1-benzoxabismole
• CAS No.: 121882-77-7
• Molecular Formula: C₂₃H₁₈BiClF₆O
• Molecular Weight: 668.819
• Mol file: 121882-77-7.mol

Synonyms:3,3-bis(trifluoromethyl)-1-chloro-1,1-bis(p-methylphenyl)-3H-2,1-benzoxabismole

Chemical Property of 3,3-bis(trifluoromethyl)-1-chloro-1,1-bis(p-methylphenyl)-3H-2,1-benzoxabismole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of 3,3-bis(trifluoromethyl)-1-chloro-1,1-bis(p-methylphenyl)-3H-2,1-benzoxabismole

There total 4 articles about 3,3-bis(trifluoromethyl)-1-chloro-1,1-bis(p-methylphenyl)-3H-2,1-benzoxabismole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

sulfuryl dichloride (7791-25-5) + 3,3-bis(trifluoromethyl)-1,1,1-tris(p-methylphenyl)-3H-2,1-benzoxabismole (121895-04-3) → 3,3-bis(trifluoromethyl)-1-chloro-1,1-bis(p-methylphenyl)-3H-2,1-benzoxabismole (121882-77-7)

Guidance literature:

In dichloromethane; Ar; addn. of 2.5 mmol SO2Cl2 to a solution of 2 mmol of the starting oxabismole at -78 ° C; the solution was warmed to room temperature and stirred for 14 h;; evaporation in vacuo; recrystn. of the residue; elem. anal.;;

DOI:10.1021/om00029a047

Reference yield: 81.0%

sulfuryl dichloride (7791-25-5) + 3,3-bis(trifluoromethyl)-1-methyl-1,1-bis(p-methylphenyl)-3H-2,1-benzoxabismole (148419-41-4) → 3,3-bis(trifluoromethyl)-1-chloro-1-(p-(trifluoromethyl)phenyl)-1-(p-methylphenyl)-3H-2,1-benzoxabismole (121882-79-9) + 3,3-bis(trifluoromethyl)-1-chloro-1,1-bis(p-methylphenyl)-3H-2,1-benzoxabismole (121882-77-7)

Guidance literature:

In dichloromethane; Ar; addn. of SO2Cl2 to a solution of the starting oxabismole at -78 ° C; the solution was warmed to room temperature and stirred for 14 h;; evaporation in vacuo; thin layer chromy (ethyl acetate, hexane); elem. anal.;;

DOI:10.1021/om00029a047

Reference yield: 61.0%

3,3-bis(trifluoromethyl)-1,1,1-tris(p-methylphenyl)-3H-2,1-benzoxabismole (121895-04-3) + ethyl 3-(chloroformyl)propionate (14794-31-1,97900-84-0) → 3,3-bis(trifluoromethyl)-1-chloro-1,1-bis(p-methylphenyl)-3H-2,1-benzoxabismole (121882-77-7) + tri(p-tolyl)bismuth (5142-75-6)

Guidance literature:

In benzene; byproducts: (CF3)2C(C6H4)(Cl)(OCOCH2CH2COC2H5); addn. of ethyl succinyl chloride at room temperature; stirring for 8.5 h at 50 ° C;; thin layer chromatography (ethyl acetate:hexane=1:5);;

DOI:10.1021/om00029a047

upstream raw materials:

sulfuryl dichloride

3,3-bis(trifluoromethyl)-1-methyl-1,1-bis(p-methylphenyl)-3H-2,1-benzoxabismole

3,3-bis(trifluoromethyl)-1,1,1-tris(p-methylphenyl)-3H-2,1-benzoxabismole

4-methoxy-benzoyl chloride

Downstream raw materials:

3,3-bis(trifluoromethyl)-1-(p-(trifluoromethyl)phrnyl)-1,1-bis(p-methylphenyl)-3H-2,1-benzoxabismole

3,3-bis(trifluoromethyl)-1-phenylethynyl-1,1-bis(p-methylphenyl)-3H-2,1-benzoxabismole