erythro-2(e)-(α-hydroxybenzyl)-4-phenylpiperidine

Base Information

• Chemical Name: erythro-2(e)-(α-hydroxybenzyl)-4-phenylpiperidine
• CAS No.: 88131-88-8
• Molecular Formula: C₁₈H₂₁NO
• Molecular Weight: 267.371
• Mol file: 88131-88-8.mol

Synonyms:erythro-2(e)-(α-hydroxybenzyl)-4-phenylpiperidine

Chemical Property of erythro-2(e)-(α-hydroxybenzyl)-4-phenylpiperidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of erythro-2(e)-(α-hydroxybenzyl)-4-phenylpiperidine

There total 4 articles about erythro-2(e)-(α-hydroxybenzyl)-4-phenylpiperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

(2R,4S)-2-((S)-Hydroxy-phenyl-methyl)-4-phenyl-piperidine-1-carboxylic acid tert-butyl ester (126503-17-1) → erythro-2(e)-(α-hydroxybenzyl)-4-phenylpiperidine (88131-88-8)

Guidance literature:

With sodium hydroxide; In ethanol; Heating;

DOI:10.1021/jo00296a008

Reference yield: 90.0%

erythro-α-(4-phenylpiperidin-2(e)-yl)benzyl 2,2-diethylbutanoate (88131-91-3,88131-92-4) → erythro-2(e)-(α-hydroxybenzyl)-4-phenylpiperidine (88131-88-8)

Guidance literature:

With potassium tert-butylate; water; In tert-butyl alcohol; Heating;

DOI:10.1021/ja00316a033

Reference yield:

tert-butyl 4-phenylpiperidine-1-carboxylate (123387-49-5) → erythro-2(e)-(α-hydroxybenzyl)-4-phenylpiperidine (88131-88-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) TMEDA, s-BuLi / 1.) ether, -20 deg C, 2.) ether, -78 deg C to r.t.

2: 92 percent / sodium hydroxide / ethanol / Heating

With sodium hydroxide; N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium; In ethanol;

DOI:10.1021/jo00296a008

upstream raw materials:

(2R,4S)-2-((S)-Hydroxy-phenyl-methyl)-4-phenyl-piperidine-1-carboxylic acid tert-butyl ester

erythro-α-(4-phenylpiperidin-2(e)-yl)benzyl 2,2-diethylbutanoate

tert-butyl 4-phenylpiperidine-1-carboxylate

benzaldehyde