exo-2-chloro-exo-3-(phenylsulfenyl)-5-cyano-6,6-diphenylbicyclo<3.1.0>hexane

Base Information

Chemical Name:exo-2-chloro-exo-3-(phenylsulfenyl)-5-cyano-6,6-diphenylbicyclo<3.1.0>hexane
CAS No.:75011-57-3
Molecular Formula:C₂₅H₂₀ClNS
Molecular Weight:401.96
Hs Code.:

Synonyms:exo-2-chloro-exo-3-(phenylsulfenyl)-5-cyano-6,6-diphenylbicyclo<3.1.0>hexane

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of exo-2-chloro-exo-3-(phenylsulfenyl)-5-cyano-6,6-diphenylbicyclo<3.1.0>hexane

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Technology Process of exo-2-chloro-exo-3-(phenylsulfenyl)-5-cyano-6,6-diphenylbicyclo<3.1.0>hexane

There total 5 articles about exo-2-chloro-exo-3-(phenylsulfenyl)-5-cyano-6,6-diphenylbicyclo<3.1.0>hexane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 75011-44-8
endo-2-hydroxy-exo-3-(phenylsulfenyl)-5-cyano-6,6-diphenylbicyclo<3.1.0>hexane

: 75011-57-3
exo-2-chloro-exo-3-(phenylsulfenyl)-5-cyano-6,6-diphenylbicyclo<3.1.0>hexane

Guidance literature:: With thionyl chloride; In pyridine; benzene; for 16h; Heating;
DOI:10.1021/jo01312a013

Reference yield:

: 34250-16-3
3-oxocyclopent-1-ene-1-carbonitrile

: 75011-57-3
exo-2-chloro-exo-3-(phenylsulfenyl)-5-cyano-6,6-diphenylbicyclo<3.1.0>hexane

Guidance literature:: Multi-step reaction with 4 steps

1: 87 percent / diethyl ether / 1080 h / Ambient temperature

2: 1) LDA, 2) HMPA / 1) -78 deg C, 30 min, THF, hexane, 2) room temperature, 1 h

3: 83 percent / NaBH₄ / methanol / 2 h / Ambient temperature

4: 54 percent / SOCl₂ / benzene; pyridine / 16 h / Heating

With N,N,N,N,N,N-hexamethylphosphoric triamide; sodium tetrahydroborate; thionyl chloride; lithium diisopropyl amide; In pyridine; methanol; diethyl ether; benzene;
DOI:10.1021/jo01312a013

Reference yield:

: 75011-39-1
5-cyano-6,6-diphenylbicyclo<3.1.0>hexan-2-one

: 75011-57-3
exo-2-chloro-exo-3-(phenylsulfenyl)-5-cyano-6,6-diphenylbicyclo<3.1.0>hexane

Guidance literature:: Multi-step reaction with 3 steps

1: 1) LDA, 2) HMPA / 1) -78 deg C, 30 min, THF, hexane, 2) room temperature, 1 h

2: 83 percent / NaBH₄ / methanol / 2 h / Ambient temperature

3: 54 percent / SOCl₂ / benzene; pyridine / 16 h / Heating

With N,N,N,N,N,N-hexamethylphosphoric triamide; sodium tetrahydroborate; thionyl chloride; lithium diisopropyl amide; In pyridine; methanol; benzene;
DOI:10.1021/jo01312a013