Chemical Property of Sapacitabine
Chemical Property:
- Refractive Index:1.574
- PKA:10.04±0.20(Predicted)
- PSA：137.47000
- Density:1.21 g/cm3
- LogP:4.12648
- Storage Temp.:-20°C Freezer, Under inert atmosphere
- Solubility.:DMSO (Slightly), Methanol (Slightly, Heated)
- XLogP3:5.2
- Hydrogen Bond Donor Count:3
- Hydrogen Bond Acceptor Count:6
- Rotatable Bond Count:17
- Exact Mass:490.31552045
- Heavy Atom Count:35
- Complexity:775
- Purity/Quality:
-
99%, *data from raw suppliers
Sapacitabine *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
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SDS file from LookChem
Useful:
- Canonical SMILES:CCCCCCCCCCCCCCCC(=O)NC1=NC(=O)N(C=C1)C2C(C(C(O2)CO)O)C#N
- Isomeric SMILES:CCCCCCCCCCCCCCCC(=O)NC1=NC(=O)N(C=C1)[C@H]2[C@H]([C@@H]([C@H](O2)CO)O)C#N
- Recent ClinicalTrials:A Study of Oral Sapacitabine in Elderly Patients With Newly Diagnosed Acute Myeloid Leukemia
- Recent EU Clinical Trials:A Phase III Randomized Study of Oral Sapacitabine in Elderly Patients with Newly Diagnosed Acute Myeloid Leukemia
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Uses
Sapacitabine, it is an orally available nucleoside analog prodrug of CNDAC that acts through a dual mechanism. It has potential use in chemotherapy.
