Amino-{3-[4-(amino-carboxy-methyl)-2-chloro-phenoxy]-4-hydroxy-phenyl}-acetic acid

Base Information

• Chemical Name: Amino-{3-[4-(amino-carboxy-methyl)-2-chloro-phenoxy]-4-hydroxy-phenyl}-acetic acid
• CAS No.: 155435-50-0
• Molecular Formula: C₁₆H₁₅ClN₂O₆
• Molecular Weight: 366.758
• Mol file: 155435-50-0.mol

Synonyms:Amino-{3-[4-(amino-carboxy-methyl)-2-chloro-phenoxy]-4-hydroxy-phenyl}-acetic acid

Chemical Property of Amino-{3-[4-(amino-carboxy-methyl)-2-chloro-phenoxy]-4-hydroxy-phenyl}-acetic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Amino-{3-[4-(amino-carboxy-methyl)-2-chloro-phenoxy]-4-hydroxy-phenyl}-acetic acid

There total 1 articles about Amino-{3-[4-(amino-carboxy-methyl)-2-chloro-phenoxy]-4-hydroxy-phenyl}-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

kistamicin A → tyrosine (556-02-5,18875-48-4,25619-78-7,30704-25-7) + 2-amino-2-(3,5-dihydroxyphenyl)acetic acid (146255-66-5,162870-29-3,19641-83-9) + Amino-{3-[4-(amino-carboxy-methyl)-2-chloro-phenoxy]-4-hydroxy-phenyl}-acetic acid (155435-50-0) + 2-Amino-3-{6-[3-[4-(2-amino-2-carboxy-ethyl)-phenoxy]-5-(amino-carboxy-methyl)-2-hydroxy-phenyl]-1H-indol-3-yl}-propionic acid

Guidance literature:

With hydrogenchloride; mercaptoacetic acid; at 110 ℃; for 24h;

DOI:10.7164/antibiotics.46.1812

Reference yield:

Amino-{3-[4-(amino-carboxy-methyl)-2-chloro-phenoxy]-4-hydroxy-phenyl}-acetic acid (155435-50-0) → Acetylamino-{3-[4-(acetylamino-carboxy-methyl)-2-chloro-phenoxy]-4-methoxy-phenyl}-acetic acid

Guidance literature:

Multi-step reaction with 3 steps

1: methanol / 1 h / Ambient temperature

2: 3.7 mg / diethyl ether

3: 1.6 mg / 0.1 M KOH / methanol / 0.5 h / Heating

With potassium hydroxide; In methanol; diethyl ether;

DOI:10.7164/antibiotics.46.1812

Reference yield:

Amino-{3-[4-(amino-carboxy-methyl)-2-chloro-phenoxy]-4-hydroxy-phenyl}-acetic acid (155435-50-0) → Acetylamino-{3-[4-(acetylamino-methoxycarbonyl-methyl)-2-chloro-phenoxy]-4-methoxy-phenyl}-acetic acid methyl ester (155435-51-1)

Guidance literature:

Multi-step reaction with 2 steps

1: methanol / 1 h / Ambient temperature

2: 3.7 mg / diethyl ether

In methanol; diethyl ether;

DOI:10.7164/antibiotics.46.1812

Downstream raw materials:

Acetylamino-{3-[4-(acetylamino-methoxycarbonyl-methyl)-2-chloro-phenoxy]-4-methoxy-phenyl}-acetic acid methyl ester