[(1R,2R)-2-Chloro-1-phenyl-2-((R)-toluene-4-sulfinyl)-propyl]-phenyl-amine

Base Information

Chemical Name:[(1R,2R)-2-Chloro-1-phenyl-2-((R)-toluene-4-sulfinyl)-propyl]-phenyl-amine
CAS No.:122406-39-7
Molecular Formula:C₂₂H₂₂ClNOS
Molecular Weight:383.942
Hs Code.:

Synonyms:[(1R,2R)-2-Chloro-1-phenyl-2-((R)-toluene-4-sulfinyl)-propyl]-phenyl-amine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of [(1R,2R)-2-Chloro-1-phenyl-2-((R)-toluene-4-sulfinyl)-propyl]-phenyl-amine

Chemical Property:

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Technology Process of [(1R,2R)-2-Chloro-1-phenyl-2-((R)-toluene-4-sulfinyl)-propyl]-phenyl-amine

There total 3 articles about [(1R,2R)-2-Chloro-1-phenyl-2-((R)-toluene-4-sulfinyl)-propyl]-phenyl-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 50635-71-7,50635-72-8,31350-93-3
1-chloroethyl p-tolyl sulfoxide

: 538-51-2
benzylidene phenylamine

: 119487-82-0,122406-24-0,122406-39-7
[(1S,2S)-2-Chloro-1-phenyl-2-(toluene-4-sulfinyl)-propyl]-phenyl-amine

Guidance literature:: With lithium diisopropyl amide; In tetrahydrofuran; at -60 ℃;
DOI:10.1016/S0040-4039(00)80425-6

Reference yield:

: 50635-71-7,50635-72-8,31350-93-3
1-chloroethyl p-tolyl sulfoxide

: 538-51-2
benzylidene phenylamine

: 119487-82-0,122406-24-0,122406-39-7
[(1S,2S)-2-Chloro-1-phenyl-2-((S)-toluene-4-sulfinyl)-propyl]-phenyl-amine

Guidance literature:: With lithium diisopropyl amide; Yield given. Multistep reaction; 1.) THF, -60 deg C, 15 min, 2.) THF, -60 deg C, 5 min;
DOI:10.1021/jo00277a041

Reference yield:

: 538-51-2
benzylidene phenylamine

: 31350-93-3,50635-71-7,50635-72-8
(-)-(R)-1-chloroethyl p-tolyl sulfoxide

: 122406-39-7
[(1R,2R)-2-Chloro-1-phenyl-2-((R)-toluene-4-sulfinyl)-propyl]-phenyl-amine

Guidance literature:: With lithium diisopropyl amide; Multistep reaction; 1.) THF, -60 deg C, 15 min, 2.) THF, -60 deg C, 5 min;
DOI:10.1021/jo00277a041