2-((3-(5-(3-(cyclopropylsulfonyl)phenyl)-3-methyl-9H-pyrido[2,3-b]indol-8-yloxy)propyl)(ethyl)amino)ethyl dihydrogen phosphate

Base Information

Chemical Name:2-((3-(5-(3-(cyclopropylsulfonyl)phenyl)-3-methyl-9H-pyrido[2,3-b]indol-8-yloxy)propyl)(ethyl)amino)ethyl dihydrogen phosphate
CAS No.:1020204-20-9
Molecular Formula:C₂₈H₃₄N₃O₇PS
Molecular Weight:587.634
Hs Code.:

Synonyms:2-((3-(5-(3-(cyclopropylsulfonyl)phenyl)-3-methyl-9H-pyrido[2,3-b]indol-8-yloxy)propyl)(ethyl)amino)ethyl dihydrogen phosphate

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Chemical Property of 2-((3-(5-(3-(cyclopropylsulfonyl)phenyl)-3-methyl-9H-pyrido[2,3-b]indol-8-yloxy)propyl)(ethyl)amino)ethyl dihydrogen phosphate

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Technology Process of 2-((3-(5-(3-(cyclopropylsulfonyl)phenyl)-3-methyl-9H-pyrido[2,3-b]indol-8-yloxy)propyl)(ethyl)amino)ethyl dihydrogen phosphate

There total 10 articles about 2-((3-(5-(3-(cyclopropylsulfonyl)phenyl)-3-methyl-9H-pyrido[2,3-b]indol-8-yloxy)propyl)(ethyl)amino)ethyl dihydrogen phosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 2-((3-(5-(3-(cyclopropylsulfonyl)phenyl)-3-methyl-9H-pyrido[2,3-b]indol-8-yloxy)propyl)(ethyl)amino)ethyl dihydrogen phosphate dihydrochloride

: 1020204-20-9
2-((3-(5-(3-(cyclopropylsulfonyl)phenyl)-3-methyl-9H-pyrido[2,3-b]indol-8-yloxy)propyl)(ethyl)amino)ethyl dihydrogen phosphate

Guidance literature:: With cyclohexane-1,2-epoxide; In methanol; for 48h;

Reference yield:

: 1020206-02-3
1-(3-(benzyloxy)propoxy)-4-chloro-2-iodobenzene

: 1020204-20-9
2-((3-(5-(3-(cyclopropylsulfonyl)phenyl)-3-methyl-9H-pyrido[2,3-b]indol-8-yloxy)propyl)(ethyl)amino)ethyl dihydrogen phosphate

Guidance literature:: Multi-step reaction with 9 steps

1.1: sodium t-butanolate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 20 - 90 °C / Inert atmosphere

2.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / palladium diacetate / N,N-dimethyl-formamide / 6 h / 155 °C / Inert atmosphere

3.1: formic acid / palladium 10% on activated carbon / methanol / 24 h / Inert atmosphere

4.1: 1H-imidazole; iodine; triphenylphosphine / dichloromethane / 16 h / 20 °C / Inert atmosphere

5.1: N,N-dimethyl-formamide / 4 h / 50 °C / Inert atmosphere

6.1: caesium carbonate / bis(dibenzylideneacetone)-palladium⁽⁰⁾; tricyclohexylphosphine / 1,4-dioxane; toluene / 6 h / Reflux; Inert atmosphere

7.1: 1H-tetrazole / N,N-dimethyl-formamide; acetonitrile / 3 h / 20 °C / Inert atmosphere

7.2: 1.5 h / -60 °C

8.1: hydrogenchloride / 1,4-dioxane / 16 h / 20 °C

9.1: cyclohexane-1,2-epoxide / methanol / 48 h

With 1H-imidazole; 1H-tetrazole; hydrogenchloride; formic acid; iodine; cyclohexane-1,2-epoxide; caesium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; triphenylphosphine; sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium 10% on activated carbon; palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; bis(dibenzylideneacetone)-palladium⁽⁰⁾; tricyclohexylphosphine; In 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide; toluene; acetonitrile;

Reference yield:

: 1020206-07-8
3-(5-chloro-3-methyl-9H-pyrido[2,3-b]indol-8-yloxy)propan-1-ol

: 1020204-20-9
2-((3-(5-(3-(cyclopropylsulfonyl)phenyl)-3-methyl-9H-pyrido[2,3-b]indol-8-yloxy)propyl)(ethyl)amino)ethyl dihydrogen phosphate

Guidance literature:: Multi-step reaction with 6 steps

1.1: 1H-imidazole; iodine; triphenylphosphine / dichloromethane / 16 h / 20 °C / Inert atmosphere

2.1: N,N-dimethyl-formamide / 4 h / 50 °C / Inert atmosphere

3.1: caesium carbonate / bis(dibenzylideneacetone)-palladium⁽⁰⁾; tricyclohexylphosphine / 1,4-dioxane; toluene / 6 h / Reflux; Inert atmosphere

4.1: 1H-tetrazole / N,N-dimethyl-formamide; acetonitrile / 3 h / 20 °C / Inert atmosphere

4.2: 1.5 h / -60 °C

5.1: hydrogenchloride / 1,4-dioxane / 16 h / 20 °C

6.1: cyclohexane-1,2-epoxide / methanol / 48 h

With 1H-imidazole; 1H-tetrazole; hydrogenchloride; iodine; cyclohexane-1,2-epoxide; caesium carbonate; triphenylphosphine; bis(dibenzylideneacetone)-palladium⁽⁰⁾; tricyclohexylphosphine; In 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide; toluene; acetonitrile;