1-(4-(4-(1H-pyrazol-4-yl)-6-(pyridin-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)phenyl)cyclobutanamine

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Chemical Name:1-(4-(4-(1H-pyrazol-4-yl)-6-(pyridin-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)phenyl)cyclobutanamine
CAS No.:1439395-60-4
Molecular Formula:C₂₄H₂₁N₇
Molecular Weight:407.478
Hs Code.:

Synonyms:1-(4-(4-(1H-pyrazol-4-yl)-6-(pyridin-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)phenyl)cyclobutanamine

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Chemical Property of 1-(4-(4-(1H-pyrazol-4-yl)-6-(pyridin-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)phenyl)cyclobutanamine

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Technology Process of 1-(4-(4-(1H-pyrazol-4-yl)-6-(pyridin-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)phenyl)cyclobutanamine

There total 5 articles about 1-(4-(4-(1H-pyrazol-4-yl)-6-(pyridin-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)phenyl)cyclobutanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1439395-62-6
tert-butyl 1-(4-(4-(1H-pyrazol-4-yl)-6-(pyridin-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)phenyl)cyclobutylcarbamate

: 1439395-60-4
1-(4-(4-(1H-pyrazol-4-yl)-6-(pyridin-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)phenyl)cyclobutanamine

Guidance literature:: With hydrogenchloride; In ethyl acetate; at 0 - 20 ℃; for 4h; Inert atmosphere;

Reference yield:

: 1439395-40-0
tert-butyl 1-(4-(6-chloro-5-(pyridin-2-ylethynyl)pyrimidin-4-ylamino)phenyl)cyclobutylcarbamate

: 1439395-60-4
1-(4-(4-(1H-pyrazol-4-yl)-6-(pyridin-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)phenyl)cyclobutanamine

Guidance literature:: Multi-step reaction with 3 steps

1: caesium carbonate; bis(tri-t-butylphosphine)palladium⁽⁰⁾; potassium fluoride / 1,4-dioxane / 1 h / 130 °C / Inert atmosphere; Microwave irradiation

2: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium carbonate / 1,4-dioxane; water / 4 h / 100 °C / Inert atmosphere

3: hydrogenchloride / ethyl acetate / 4 h / 0 - 20 °C / Inert atmosphere

With hydrogenchloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium fluoride; bis(tri-t-butylphosphine)palladium⁽⁰⁾; caesium carbonate; In 1,4-dioxane; water; ethyl acetate;

Reference yield:

: 1439395-35-3
tert-butyl 1-(4-(4-chloro-6-(pyridin-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)phenyl)cyclobutylcarbamate

: 1439395-60-4
1-(4-(4-(1H-pyrazol-4-yl)-6-(pyridin-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)phenyl)cyclobutanamine

Guidance literature:: Multi-step reaction with 2 steps

1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium carbonate / 1,4-dioxane; water / 4 h / 100 °C / Inert atmosphere

2: hydrogenchloride / ethyl acetate / 4 h / 0 - 20 °C / Inert atmosphere

With hydrogenchloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium carbonate; In 1,4-dioxane; water; ethyl acetate;