4-amino-6-(((1S)-1-(8-fluoro-2-(2-(methyl-sulfonyl)phenyl)-3-quinolinyl)ethyl)amino)-5-pyrimidinecarbonitrile

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Chemical Name:4-amino-6-(((1S)-1-(8-fluoro-2-(2-(methyl-sulfonyl)phenyl)-3-quinolinyl)ethyl)amino)-5-pyrimidinecarbonitrile
CAS No.:1464832-30-1
Molecular Formula:C₂₃H₁₉FN₆O₂S
Molecular Weight:462.507
Hs Code.:

Synonyms:4-amino-6-(((1S)-1-(8-fluoro-2-(2-(methyl-sulfonyl)phenyl)-3-quinolinyl)ethyl)amino)-5-pyrimidinecarbonitrile

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Chemical Property of 4-amino-6-(((1S)-1-(8-fluoro-2-(2-(methyl-sulfonyl)phenyl)-3-quinolinyl)ethyl)amino)-5-pyrimidinecarbonitrile

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Technology Process of 4-amino-6-(((1S)-1-(8-fluoro-2-(2-(methyl-sulfonyl)phenyl)-3-quinolinyl)ethyl)amino)-5-pyrimidinecarbonitrile

There total 11 articles about 4-amino-6-(((1S)-1-(8-fluoro-2-(2-(methyl-sulfonyl)phenyl)-3-quinolinyl)ethyl)amino)-5-pyrimidinecarbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 1464832-39-0
(1S)-1-(8-fluoro-2-(2-(methylsulfonyl)phenyl)-3-quinolinyl)ethanamine

: 60025-09-4
4-amino-6-chloropyrimidine-5-carbonitrile

: 1464832-30-1
4-amino-6-(((1S)-1-(8-fluoro-2-(2-(methyl-sulfonyl)phenyl)-3-quinolinyl)ethyl)amino)-5-pyrimidinecarbonitrile

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In butan-1-ol; at 110 - 120 ℃; for 5h; Inert atmosphere;

Reference yield:

: 71738-83-5
8-fluoroquinolin-2(1H)-one

: 1464832-30-1
4-amino-6-(((1S)-1-(8-fluoro-2-(2-(methyl-sulfonyl)phenyl)-3-quinolinyl)ethyl)amino)-5-pyrimidinecarbonitrile

Guidance literature:: Multi-step reaction with 9 steps

1.1: trichlorophosphate / 2 h / 125 °C

2.1: lithium diisopropyl amide / tetrahydrofuran / 0.33 h / -78 °C

2.2: 0.5 h / -78 °C

3.1: manganese(IV) oxide / toluene / 2 h / Reflux

4.1: B-chlorodiisopinocampheylborane / tetrahydrofuran / -55 - 20 °C

5.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 0 - 20 °C

6.1: potassium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / N,N-dimethyl-formamide / 3 h / 100 °C / Inert atmosphere

7.1: Oxone / water; dichloromethane / 72 h / 20 °C

8.1: hydrazine hydrate / ethanol / 3 h / 65 °C

9.1: N-ethyl-N,N-diisopropylamine / butan-1-ol / 5 h / 110 - 120 °C / Inert atmosphere

With manganese(IV) oxide; Oxone; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; di-isopropyl azodicarboxylate; potassium carbonate; hydrazine hydrate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; B-chlorodiisopinocampheylborane; lithium diisopropyl amide; trichlorophosphate; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; butan-1-ol;

Reference yield:

: 1065481-24-4
(2E)-N-(2-fluorophenyl)-3-phenylprop-2-enamide

: 1464832-30-1
4-amino-6-(((1S)-1-(8-fluoro-2-(2-(methyl-sulfonyl)phenyl)-3-quinolinyl)ethyl)amino)-5-pyrimidinecarbonitrile

Guidance literature:: Multi-step reaction with 10 steps

1.1: aluminum (III) chloride / chlorobenzene / 3 h / 125 °C

2.1: trichlorophosphate / 2 h / 125 °C

3.1: lithium diisopropyl amide / tetrahydrofuran / 0.33 h / -78 °C

3.2: 0.5 h / -78 °C

4.1: manganese(IV) oxide / toluene / 2 h / Reflux

5.1: B-chlorodiisopinocampheylborane / tetrahydrofuran / -55 - 20 °C

6.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 0 - 20 °C

7.1: potassium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / N,N-dimethyl-formamide / 3 h / 100 °C / Inert atmosphere

8.1: Oxone / water; dichloromethane / 72 h / 20 °C

9.1: hydrazine hydrate / ethanol / 3 h / 65 °C

10.1: N-ethyl-N,N-diisopropylamine / butan-1-ol / 5 h / 110 - 120 °C / Inert atmosphere

With manganese(IV) oxide; aluminum (III) chloride; Oxone; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; di-isopropyl azodicarboxylate; potassium carbonate; hydrazine hydrate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; B-chlorodiisopinocampheylborane; lithium diisopropyl amide; trichlorophosphate; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide; chlorobenzene; toluene; butan-1-ol;