(R)-4-(Benzylamino-methyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester

Base Information

Chemical Name:(R)-4-(Benzylamino-methyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester
CAS No.:191021-42-8
Molecular Formula:C₁₈H₂₈N₂O₃
Molecular Weight:320.432
Hs Code.:

Synonyms:(R)-4-(Benzylamino-methyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester

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Chemical Property of (R)-4-(Benzylamino-methyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester

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Technology Process of (R)-4-(Benzylamino-methyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester

There total 1 articles about (R)-4-(Benzylamino-methyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 102308-32-7
(4S)-4-formyl-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester

: 100-46-9
benzylamine

: 191021-42-8
(R)-4-(Benzylamino-methyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester

Guidance literature:: With hydrogenchloride; sodium cyanoborohydride; In methanol; for 16h; Yield given; Ambient temperature;
DOI:10.1080/00397919708003390

Reference yield:

: 76792-22-8,10323-40-7,26782-75-2,565-74-2
(R)-2-bromoisovaleric acid

: 191021-42-8
(R)-4-(Benzylamino-methyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester

: C₂₃H₃₅BrN₂O₄

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In dichloromethane; at 20 ℃; for 1h;
DOI:10.1016/j.bmcl.2021.127961

Reference yield:

: 191021-42-8
(R)-4-(Benzylamino-methyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester

: ((R)-1-Benzyl-2,4-dioxo-hexahydro-pyrimidin-5-yl)-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: tetrahydrofuran / 16 h / Ambient temperature

2: CF₃CO₂H / CH₂Cl₂ / 0.25 h / Ambient temperature

3: Jones reagent / acetone / 2 h / Ambient temperature; further reagents

With jones reagent; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; acetone;
DOI:10.1080/00397919708003390