O-[(1S)-(3-cyclohexyl-isoxazol-5-yl)-ethyl]-hydroxylamine

Base Information

Chemical Name:O-[(1S)-(3-cyclohexyl-isoxazol-5-yl)-ethyl]-hydroxylamine
CAS No.:782450-81-1
Molecular Formula:C₁₁H₁₈N₂O₂
Molecular Weight:210.276
Hs Code.:

Synonyms:O-[(1S)-(3-cyclohexyl-isoxazol-5-yl)-ethyl]-hydroxylamine

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Chemical Property of O-[(1S)-(3-cyclohexyl-isoxazol-5-yl)-ethyl]-hydroxylamine

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Technology Process of O-[(1S)-(3-cyclohexyl-isoxazol-5-yl)-ethyl]-hydroxylamine

There total 2 articles about O-[(1S)-(3-cyclohexyl-isoxazol-5-yl)-ethyl]-hydroxylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 2914-69-4
(S)-(-)-3-butyn-2-ol

: 4715-11-1
cyclohexanecarbaldoxime

: 782450-81-1
O-[(1S)-(3-cyclohexyl-isoxazol-5-yl)-ethyl]-hydroxylamine

Guidance literature:: (S)-(-)-3-butyn-2-ol; With polystyrene-bound N-hydroxyphthalimide resin; tributylphosphine; diamide; In tetrahydrofuran; dichloromethane; at 20 ℃; for 6h;

cyclohexanecarbaldoxime; With N-Bromosuccinimide; sodium hydrogencarbonate; In dichloromethane; at 35 ℃; for 12h;

With hydrazine; In dichloromethane; for 1h;
DOI:10.1016/j.tet.2004.05.109

Reference yield:

: 2043-61-0
cyclohexanecarbaldehyde

: 782450-81-1
O-[(1S)-(3-cyclohexyl-isoxazol-5-yl)-ethyl]-hydroxylamine

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydroxylamine hydrochloride; Et₃N / CH₂Cl₂ / 1 h

1.2: aq. HCl / CH₂Cl₂

2.1: polystyrene-bound N-hydroxyphthalimide resin; azodicarboxylic acid bis[dimethylamide]; P(n-Bu)3 / CH₂Cl₂; tetrahydrofuran / 6 h / 20 °C

2.2: NBS; NaHCO₃ / CH₂Cl₂ / 12 h / 35 °C

2.3: 96 percent / NH₂NH₂ / CH₂Cl₂ / 1 h

With polystyrene-bound N-hydroxyphthalimide resin; tributylphosphine; diamide; hydroxylamine hydrochloride; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.tet.2004.05.109

Reference yield:

: 782450-81-1
O-[(1S)-(3-cyclohexyl-isoxazol-5-yl)-ethyl]-hydroxylamine

: C₁₁H₁₆O₅

: (Z)-1,2-O-cyclohexylidene-α-D-xylopentodialdo-1,4-furanose O-[(1S)-(3-cyclohexyl-isoxazol-5-yl)-ethyl]-oxime

: (E)-1,2-O-cyclohexylidene-α-D-xylopentodialdo-1,4-furanose O-[(1S)-(3-cyclohexyl-isoxazol-5-yl)-ethyl]-oxime

Guidance literature:: O-[(1S)-(3-cyclohexyl-isoxazol-5-yl)-ethyl]-hydroxylamine; C₁₁H₁₆O₅; In 1,2-dichloro-ethane; at 120 ℃; for 0.25h; microwave irradiation;

With PL-MIA resin; In dichloromethane; at 20 ℃; for 4h;
DOI:10.1016/j.tet.2004.05.109