methyl 3-(2-{[6-(3,5-dimethylphenoxy)-2-(methylamino)pyridin-3-yl]amino}-2-oxoethoxy)benzoate

Base Information

Chemical Name:methyl 3-(2-{[6-(3,5-dimethylphenoxy)-2-(methylamino)pyridin-3-yl]amino}-2-oxoethoxy)benzoate
CAS No.:1072004-68-2
Molecular Formula:C₂₄H₂₅N₃O₅
Molecular Weight:435.48
Hs Code.:

Synonyms:methyl 3-(2-{[6-(3,5-dimethylphenoxy)-2-(methylamino)pyridin-3-yl]amino}-2-oxoethoxy)benzoate

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Chemical Property of methyl 3-(2-{[6-(3,5-dimethylphenoxy)-2-(methylamino)pyridin-3-yl]amino}-2-oxoethoxy)benzoate

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Technology Process of methyl 3-(2-{[6-(3,5-dimethylphenoxy)-2-(methylamino)pyridin-3-yl]amino}-2-oxoethoxy)benzoate

There total 5 articles about methyl 3-(2-{[6-(3,5-dimethylphenoxy)-2-(methylamino)pyridin-3-yl]amino}-2-oxoethoxy)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1072004-67-1
3-amino-6-(3,5-dimethylphenoxy)-2-N-methylaminopyridine

: 113496-11-0
[3-(methoxycarbonyl)phenoxy]acetic acid

: 1072004-68-2
methyl 3-(2-{[6-(3,5-dimethylphenoxy)-2-(methylamino)pyridin-3-yl]amino}-2-oxoethoxy)benzoate

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 18h; Inert atmosphere;
DOI:10.1016/j.bmc.2018.09.005

Reference yield:

: 33742-70-0
6-chloro-N-methyl-3-nitropyridin-2-amine

: 1072004-68-2
methyl 3-(2-{[6-(3,5-dimethylphenoxy)-2-(methylamino)pyridin-3-yl]amino}-2-oxoethoxy)benzoate

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydride / N,N-dimethyl-formamide / 10 h / 80 °C / Inert atmosphere

2: hydrogen; palladium 10% on activated carbon / ethanol / 6 h

3: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 18 h / 20 °C / Inert atmosphere

With palladium 10% on activated carbon; hydrogen; sodium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2018.09.005

Reference yield:

: 1072004-66-0
6-(3,5-Dimethylphenoxy)-N-methyl-3-nitropyridin-2-amine

: 1072004-68-2
methyl 3-(2-{[6-(3,5-dimethylphenoxy)-2-(methylamino)pyridin-3-yl]amino}-2-oxoethoxy)benzoate

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen; palladium 10% on activated carbon / ethanol / 6 h

2: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 18 h / 20 °C / Inert atmosphere

With palladium 10% on activated carbon; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In ethanol; dichloromethane;
DOI:10.1016/j.bmc.2018.09.005