6-(4-fluorophenyl)-1-((S)-2-methoxymethyl-pyrrolidin-1-yl)-3,4-dihydro-1H-pyridin-2-one

Base Information

Chemical Name:6-(4-fluorophenyl)-1-((S)-2-methoxymethyl-pyrrolidin-1-yl)-3,4-dihydro-1H-pyridin-2-one
CAS No.:1394905-57-7
Molecular Formula:C₁₇H₂₁FN₂O₂
Molecular Weight:304.364
Hs Code.:

Synonyms:6-(4-fluorophenyl)-1-((S)-2-methoxymethyl-pyrrolidin-1-yl)-3,4-dihydro-1H-pyridin-2-one

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Chemical Property of 6-(4-fluorophenyl)-1-((S)-2-methoxymethyl-pyrrolidin-1-yl)-3,4-dihydro-1H-pyridin-2-one

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Technology Process of 6-(4-fluorophenyl)-1-((S)-2-methoxymethyl-pyrrolidin-1-yl)-3,4-dihydro-1H-pyridin-2-one

There total 4 articles about 6-(4-fluorophenyl)-1-((S)-2-methoxymethyl-pyrrolidin-1-yl)-3,4-dihydro-1H-pyridin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 59983-39-0,187035-29-6
(S)-1-amino-2-(methoxymethyl)pyrrolidine

: 1394905-57-7
6-(4-fluorophenyl)-1-((S)-2-methoxymethyl-pyrrolidin-1-yl)-3,4-dihydro-1H-pyridin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: dichloromethane / 1 h / 20 °C

1.2: 5 h / Reflux

2.1: potassium hexamethylsilazane / tetrahydrofuran; toluene / 0.5 h / -78 °C / Inert atmosphere

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / tetrahydrofuran; water / 2 h / Inert atmosphere; Reflux

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium hexamethylsilazane; sodium carbonate; In tetrahydrofuran; dichloromethane; water; toluene; 3.1: Suzuki-Miyaura coupling;
DOI:10.1016/j.tetasy.2012.06.024

Reference yield:

: C₂₃H₂₇N₂O₆P

: 1765-93-1
4-fluoroboronic acid

: 1394905-57-7
6-(4-fluorophenyl)-1-((S)-2-methoxymethyl-pyrrolidin-1-yl)-3,4-dihydro-1H-pyridin-2-one

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In tetrahydrofuran; water; for 2h; Inert atmosphere; Reflux;
DOI:10.1016/j.tetasy.2012.06.024

Reference yield:

: 1394905-55-5
1-((S)-2-methoxymethylpyrrolidin-1-yl)-piperidine-2,6-dione

: 1394905-57-7
6-(4-fluorophenyl)-1-((S)-2-methoxymethyl-pyrrolidin-1-yl)-3,4-dihydro-1H-pyridin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: potassium hexamethylsilazane / tetrahydrofuran; toluene / 0.5 h / -78 °C / Inert atmosphere

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / tetrahydrofuran; water / 2 h / Inert atmosphere; Reflux

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium hexamethylsilazane; sodium carbonate; In tetrahydrofuran; water; toluene; 2: Suzuki-Miyaura coupling;
DOI:10.1016/j.tetasy.2012.06.024