1-(2-(1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-3-yl)thiazol-4-yl)-3-phenylurea

Base Information

Chemical Name:1-(2-(1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-3-yl)thiazol-4-yl)-3-phenylurea
CAS No.:1271802-37-9
Molecular Formula:C₂₁H₂₁N₇OS
Molecular Weight:419.51
Hs Code.:

Synonyms:1-(2-(1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-3-yl)thiazol-4-yl)-3-phenylurea

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Chemical Property of 1-(2-(1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-3-yl)thiazol-4-yl)-3-phenylurea

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Technology Process of 1-(2-(1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-3-yl)thiazol-4-yl)-3-phenylurea

There total 5 articles about 1-(2-(1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-3-yl)thiazol-4-yl)-3-phenylurea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1271808-87-7
C₂₀H₂₆N₄O₃S

: 3680-69-1
4-chloro-1H-pyrrolo[2,3-d]pyrimidine

: 1271802-37-9
1-(2-(1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-3-yl)thiazol-4-yl)-3-phenylurea

Guidance literature:: C₂₀H₂₆N₄O₃S; With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 2h;

4-chloro-1H-pyrrolo[2,3-d]pyrimidine; With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 85 ℃; for 12h;

Reference yield:

: 4138-26-5,168749-30-2
nipecotamide

: 1271802-37-9
1-(2-(1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-3-yl)thiazol-4-yl)-3-phenylurea

Guidance literature:: Multi-step reaction with 5 steps

1.1: chloroform / 20 °C

2.1: tetraphosphorus decasulfide; sodium carbonate / tetrahydrofuran / 1.5 h / 20 °C / Inert atmosphere

3.1: sodium iodide / acetone / 2 h / 50 °C

4.1: lithium hydroxide / methanol / 3 h

4.2: 12 h / 100 °C

5.1: hydrogenchloride / 1,4-dioxane / 2 h / 20 °C

5.2: 12 h / 85 °C

With hydrogenchloride; tetraphosphorus decasulfide; sodium carbonate; sodium iodide; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; chloroform; acetone;

Reference yield:

: 91419-49-7
tert-butyl 3-carbamoylpiperidine-1-carboxylate

: 1271802-37-9
1-(2-(1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-3-yl)thiazol-4-yl)-3-phenylurea

Guidance literature:: Multi-step reaction with 4 steps

1.1: tetraphosphorus decasulfide; sodium carbonate / tetrahydrofuran / 1.5 h / 20 °C / Inert atmosphere

2.1: sodium iodide / acetone / 2 h / 50 °C

3.1: lithium hydroxide / methanol / 3 h

3.2: 12 h / 100 °C

4.1: hydrogenchloride / 1,4-dioxane / 2 h / 20 °C

4.2: 12 h / 85 °C

With hydrogenchloride; tetraphosphorus decasulfide; sodium carbonate; sodium iodide; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; acetone;