(5-methyl-2-oxo-9-phenyl-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-1-yl)acetic acid

Base Information

Chemical Name:(5-methyl-2-oxo-9-phenyl-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-1-yl)acetic acid
CAS No.:1332848-59-5
Molecular Formula:C₁₈H₁₈N₂O₃
Molecular Weight:310.353
Hs Code.:

Synonyms:(5-methyl-2-oxo-9-phenyl-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-1-yl)acetic acid

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Chemical Property of (5-methyl-2-oxo-9-phenyl-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-1-yl)acetic acid

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Technology Process of (5-methyl-2-oxo-9-phenyl-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-1-yl)acetic acid

There total 5 articles about (5-methyl-2-oxo-9-phenyl-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-1-yl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 1310699-82-1
methyl (5-methyl-2-oxo-9-phenyl-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-1-yl)acetate

: 1332848-59-5
(5-methyl-2-oxo-9-phenyl-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-1-yl)acetic acid

Guidance literature:: methyl (5-methyl-2-oxo-9-phenyl-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-1-yl)acetate; With sodium hydroxide; In methanol; water; at 25 ℃;

With hydrogenchloride; In methanol; water;
DOI:10.1021/jo2008725

Reference yield:

: 1310699-71-8
5-methyl-9-phenyl-1,3,4,5-tetrahydro-2H-1,5-benzodiazepin-2-one

: 1332848-59-5
(5-methyl-2-oxo-9-phenyl-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-1-yl)acetic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide / Cooling

1.2: Cooling

2.1: sodium hydroxide / methanol; water / 25 °C

With sodium hydride; sodium hydroxide; In methanol; water; N,N-dimethyl-formamide;
DOI:10.1021/jo2008725

Reference yield:

: 1310699-89-8
N-(3-chloro-2-nitrophenyl)-N-methyl-β-alanine

: 1332848-59-5
(5-methyl-2-oxo-9-phenyl-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-1-yl)acetic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: phosphoric acid; zinc / 1,4-dioxane / 5 h / 80 °C / Reflux

2.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium carbonate; XPhos / N,N-dimethyl acetamide; water / 7 h / 100 °C / Inert atmosphere

3.1: sodium hydride / N,N-dimethyl-formamide / Cooling

3.2: Cooling

4.1: sodium hydroxide / methanol; water / 25 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; phosphoric acid; sodium hydride; potassium carbonate; sodium hydroxide; zinc; XPhos; In 1,4-dioxane; methanol; N,N-dimethyl acetamide; water; N,N-dimethyl-formamide; 2.1: Suzuki-Miyaura coupling;
DOI:10.1021/jo2008725