benzoic acid 4-{1-[2-methoxy-1-(1-{[1-(1-methoxycarbonyl-2,4-dimethyl-pent-3-enylcarbamoyl)-3-methyl-butyl]-methyl-carbamoyl}-2-methyl-propylcarbamoyl)-2-phenyl-ethylcarbamoyl]-ethylcarbamoyl}-2-methyl-4-methylamino-butyl ester

Base Information

Chemical Name:benzoic acid 4-{1-[2-methoxy-1-(1-{[1-(1-methoxycarbonyl-2,4-dimethyl-pent-3-enylcarbamoyl)-3-methyl-butyl]-methyl-carbamoyl}-2-methyl-propylcarbamoyl)-2-phenyl-ethylcarbamoyl]-ethylcarbamoyl}-2-methyl-4-methylamino-butyl ester
CAS No.:855315-50-3
Molecular Formula:C₄₈H₇₂N₆O₁₀
Molecular Weight:893.134
Hs Code.:

benzoic acid 4-{1-[2-methoxy-1-(1-{[1-(1-methoxycarbonyl-2,4-dimethyl-pent-3-enylcarbamoyl)-3-methyl-butyl]-methyl-carbamoyl}-2-methyl-propylcarbamoyl)-2-phenyl-ethylcarbamoyl]-ethylcarbamoyl}-2-methyl-4-methylamino-butyl ester

Synonyms:benzoic acid 4-{1-[2-methoxy-1-(1-{[1-(1-methoxycarbonyl-2,4-dimethyl-pent-3-enylcarbamoyl)-3-methyl-butyl]-methyl-carbamoyl}-2-methyl-propylcarbamoyl)-2-phenyl-ethylcarbamoyl]-ethylcarbamoyl}-2-methyl-4-methylamino-butyl ester

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Chemical Property of benzoic acid 4-{1-[2-methoxy-1-(1-{[1-(1-methoxycarbonyl-2,4-dimethyl-pent-3-enylcarbamoyl)-3-methyl-butyl]-methyl-carbamoyl}-2-methyl-propylcarbamoyl)-2-phenyl-ethylcarbamoyl]-ethylcarbamoyl}-2-methyl-4-methylamino-butyl ester

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Technology Process of benzoic acid 4-{1-[2-methoxy-1-(1-{[1-(1-methoxycarbonyl-2,4-dimethyl-pent-3-enylcarbamoyl)-3-methyl-butyl]-methyl-carbamoyl}-2-methyl-propylcarbamoyl)-2-phenyl-ethylcarbamoyl]-ethylcarbamoyl}-2-methyl-4-methylamino-butyl ester

There total 13 articles about benzoic acid 4-{1-[2-methoxy-1-(1-{[1-(1-methoxycarbonyl-2,4-dimethyl-pent-3-enylcarbamoyl)-3-methyl-butyl]-methyl-carbamoyl}-2-methyl-propylcarbamoyl)-2-phenyl-ethylcarbamoyl]-ethylcarbamoyl}-2-methyl-4-methylamino-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (2S,3R)-2-((S)-2-Amino-propionylamino)-3-methoxy-3-phenyl-propionic acid methyl ester

: 855315-50-3
benzoic acid 4-{1-[2-methoxy-1-(1-{[1-(1-methoxycarbonyl-2,4-dimethyl-pent-3-enylcarbamoyl)-3-methyl-butyl]-methyl-carbamoyl}-2-methyl-propylcarbamoyl)-2-phenyl-ethylcarbamoyl]-ethylcarbamoyl}-2-methyl-4-methylamino-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 80 percent / 1-hydroxybenzotriazole hydrate; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; diisopropylethylamine / CH₂Cl₂ / 4 h / 0 - 20 °C

2: LiOH / tetrahydrofuran; H₂O / 0 °C

3: 63 percent / 1-hydroxybenzotriazole hydrate; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; diisopropylethylamine / CH₂Cl₂ / 0 - 20 °C

4: trifluoroacetic acid

With lithium hydroxide; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; water;
DOI:10.1016/j.tet.2005.03.058

Reference yield:

: 855315-28-5
N-Boc-L-Val-N-Me-L-Leu-OMe

: 855315-50-3
benzoic acid 4-{1-[2-methoxy-1-(1-{[1-(1-methoxycarbonyl-2,4-dimethyl-pent-3-enylcarbamoyl)-3-methyl-butyl]-methyl-carbamoyl}-2-methyl-propylcarbamoyl)-2-phenyl-ethylcarbamoyl]-ethylcarbamoyl}-2-methyl-4-methylamino-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: LiOH*H₂O / tetrahydrofuran; H₂O / 3 h / 0 °C

2: 208 mg / 1-hydroxybenzotriazole hydrate; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; diisopropylethylamine / CH₂Cl₂ / 0 - 20 °C

3: trifluoroacetic acid / CH₂Cl₂

4: 63 percent / 1-hydroxybenzotriazole hydrate; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; diisopropylethylamine / CH₂Cl₂ / 0 - 20 °C

5: trifluoroacetic acid

With lithium hydroxide; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; water;
DOI:10.1016/j.tet.2005.03.058

Reference yield:

: 855315-41-2
(2S,3R)-2-((S)-2-tert-Butoxycarbonylamino-propionylamino)-3-methoxy-3-phenyl-propionic acid methyl ester

: 855315-50-3
benzoic acid 4-{1-[2-methoxy-1-(1-{[1-(1-methoxycarbonyl-2,4-dimethyl-pent-3-enylcarbamoyl)-3-methyl-butyl]-methyl-carbamoyl}-2-methyl-propylcarbamoyl)-2-phenyl-ethylcarbamoyl]-ethylcarbamoyl}-2-methyl-4-methylamino-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: trifluoroacetic acid / CH₂Cl₂

2: 80 percent / 1-hydroxybenzotriazole hydrate; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; diisopropylethylamine / CH₂Cl₂ / 4 h / 0 - 20 °C

3: LiOH / tetrahydrofuran; H₂O / 0 °C

4: 63 percent / 1-hydroxybenzotriazole hydrate; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; diisopropylethylamine / CH₂Cl₂ / 0 - 20 °C

5: trifluoroacetic acid

With lithium hydroxide; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; water;
DOI:10.1016/j.tet.2005.03.058