(2α,3β(R^*),4β)-(+/-)-Tetrahydro-α-hydroxy-2-octyl-5-oxo-4-<(phenylthio)methyl>-3-furanacetic acid methyl ester

Base Information

• Chemical Name: (2α,3β(R^*),4β)-(+/-)-Tetrahydro-α-hydroxy-2-octyl-5-oxo-4-<(phenylthio)methyl>-3-furanacetic acid methyl ester
• CAS No.: 107977-47-9
• Molecular Formula: C₂₂H₃₂O₅S
• Molecular Weight: 408.559

Synonyms:(2α,3β(R^*),4β)-(+/-)-Tetrahydro-α-hydroxy-2-octyl-5-oxo-4-<(phenylthio)methyl>-3-furanacetic acid methyl ester

Chemical Property of (2α,3β(R^*),4β)-(+/-)-Tetrahydro-α-hydroxy-2-octyl-5-oxo-4-<(phenylthio)methyl>-3-furanacetic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2α,3β(R^*),4β)-(+/-)-Tetrahydro-α-hydroxy-2-octyl-5-oxo-4-<(phenylthio)methyl>-3-furanacetic acid methyl ester

There total 14 articles about (2α,3β(R^*),4β)-(+/-)-Tetrahydro-α-hydroxy-2-octyl-5-oxo-4-<(phenylthio)methyl>-3-furanacetic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

(S)-((2R,3S)-2-Octyl-5-oxo-4-phenylsulfanylmethyl-tetrahydro-furan-3-yl)-(2-trimethylsilanyl-ethoxy)-acetic acid methyl ester (107977-45-7,107977-46-8) → (2α,3β(R*),4β)-(+/-)-Tetrahydro-α-hydroxy-2-octyl-5-oxo-4-<(phenylthio)methyl>-3-furanacetic acid methyl ester (107977-47-9)

Guidance literature:

With boron trifluoride diethyl etherate; In dichloromethane; at 0 - 25 ℃;

DOI:10.1016/S0040-4039(00)84792-9

Reference yield: 79.0%

(2α,3β(R*),4β)-(+/-)-Tetrahydro-α-<2-(trimethylsilyl)ethoxy>-2-octyl-5-oxo-4-<(phenylthio)methyl>-3-furanacetic acid methyl ester (107977-45-7,107977-46-8) → (2α,3β(R*),4β)-(+/-)-Tetrahydro-α-hydroxy-2-octyl-5-oxo-4-<(phenylthio)methyl>-3-furanacetic acid methyl ester (107977-47-9)

Guidance literature:

With boron trifluoride diethyl etherate; In dichloromethane; 1.) 0 deg C, 5 min, 2.) 25 deg C, 2.5 h;

DOI:10.1021/jo00034a009

Reference yield:

(2α,3β(R*))-(+/-)-Tetrahydro-4-methylene-α-<2-(trimethylsilyl)ethoxy>-2-octyl-5-oxo-3-furanacetic acid (107977-44-6) → (2α,3β(R*),4β)-(+/-)-Tetrahydro-α-hydroxy-2-octyl-5-oxo-4-<(phenylthio)methyl>-3-furanacetic acid methyl ester (107977-47-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) NaOEt / 1.) EtOH, 0 deg C, 10 min, 2.) 0 deg C, 10 min, then 25 deg C, 1 h

2: diethyl ether

3: 79 percent / BF₃ etherate / CH₂Cl₂ / 1.) 0 deg C, 5 min, 2.) 25 deg C, 2.5 h

With boron trifluoride diethyl etherate; sodium ethanolate; In diethyl ether; dichloromethane;

DOI:10.1021/jo00034a009

upstream raw materials:

(R)-Hydroxy-((2S,3S)-4-methylene-2-octyl-5-oxo-tetrahydro-furan-3-yl)-acetic acid

(2α,3β(R^*))-(+/-)-Tetrahydro-α-hydroxy-4-methylene-2-octyl-5-oxo-3-furanacetic acid methyl ester

(S)-((2R,3S)-2-Octyl-5-oxo-4-phenylsulfanylmethyl-tetrahydro-furan-3-yl)-(2-trimethylsilanyl-ethoxy)-acetic acid methyl ester

(2α,3β(R^*),4β)-(+/-)-Tetrahydro-α-<2-(trimethylsilyl)ethoxy>-2-octyl-5-oxo-4-<(phenylthio)methyl>-3-furanacetic acid methyl ester

Downstream raw materials:

(3α,3aα,4β,6aα)-(+/-)-Dihydro-4-octyl-3-<(phenylthio)methyl>furo<3,4-b>furan-2,6(3H,4H)-dione

(+/-)-isoavenaciolide

(3S,3aR,4S,6aR)-4-Octyl-3-phenylsulfanylmethyl-dihydro-furo[3,4-b]furan-2,6-dione

(-)-isoavenaciolide

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 107977-47-9 (2α,3β(R^*),4β)-(+/-)-Tetrahydro-α-hydroxy-2-octyl-5-oxo-4-<(phenylthio)methyl>-3-furanacetic acid methyl ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send