(2S,3R,4R)-4-hydroxy-2-(4-methoxybenzyl)pyrrolidin-3-yl acetate hydrochloride (1:1)

Base Information

Chemical Name:(2S,3R,4R)-4-hydroxy-2-(4-methoxybenzyl)pyrrolidin-3-yl acetate hydrochloride (1:1)
CAS No.:22862-75-5
Molecular Formula:C₁₄H₁₉NO₄*ClH
Molecular Weight:301.77
Hs Code.:
Mol file:22862-75-5.mol

Synonyms:3,4-Pyrrolidinediol,2-(p-methoxybenzyl)-, 3-acetate, hydrochloride, cis-2,3,trans-3,4-(-)- (8CI);3,4-Pyrrolidinediol, 2-[(4-methoxyphenyl)methyl]-, 3-acetate, hydrochloride,[2S-(2a,3a,4b)]-; NSC 147340

Suppliers and Price of (2S,3R,4R)-4-hydroxy-2-(4-methoxybenzyl)pyrrolidin-3-yl acetate hydrochloride (1:1)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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Total 2 raw suppliers

Chemical Property of (2S,3R,4R)-4-hydroxy-2-(4-methoxybenzyl)pyrrolidin-3-yl acetate hydrochloride (1:1)

Chemical Property:

Vapor Pressure:4.5E-07mmHg at 25°C
Boiling Point:398.7°Cat760mmHg
Flash Point:194.9°C
Density:g/cm³

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of (2S,3R,4R)-4-hydroxy-2-(4-methoxybenzyl)pyrrolidin-3-yl acetate hydrochloride (1:1)

There total 10 articles about (2S,3R,4R)-4-hydroxy-2-(4-methoxybenzyl)pyrrolidin-3-yl acetate hydrochloride (1:1) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 400009-33-8
(2R,3S,4S)-3-acetoxy-1-benzyl-4-benzyloxy-2-(4-methoxybenzyl)pyrrolidine

: 22862-75-5
(2R,3S,4S)-3-(acetyloxy)-4-hydroxy-2-(4-methoxybenzyl)pyrrolidinium chloride

Guidance literature:: With hydrogenchloride; hydrogen; palladium dihydroxide; In methanol; diethyl ether;
DOI:10.1021/ol017016u

Reference yield: 72.0%

: (2S,3R,4R)-2-azido-4-(benzyloxy)-1-(4-methoxyphenyl)-5-(tosyloxy)pentan-3-yl acetate

: 22862-75-5
(2S,3R,4R)-4-hydroxy-2-(4-methoxybenzyl)pyrrolidin-3-yl acetate hydrochloride

Guidance literature:: With hydrogenchloride; palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 12h;
DOI:10.1055/s-0035-1561365

Reference yield: 66.0%

: 865814-10-4
tert-butyl (2R,3S,4S)-3-(acetyloxy)-4-{[(tert-butoxy)carbonyl]oxy}-2-(4-methoxybenzyl)pyrrolidine-1-carboxylate

: 22862-75-5
(2R,3S,4S)-3-(acetyloxy)-4-hydroxy-2-(4-methoxybenzyl)pyrrolidinium chloride

Guidance literature:: tert-butyl (2R,3S,4S)-3-(acetyloxy)-4-{[(tert-butoxy)carbonyl]oxy}-2-(4-methoxybenzyl)pyrrolidine-1-carboxylate; With hydrogenchloride; In 1,4-dioxane; at 0 ℃; for 5h;

With water; In 1,4-dioxane; at 0 ℃; for 0.5h;
DOI:10.1002/hlca.200590143