Technology Process of N-(4-(1-(6-methylpyridin-3-yl)-4-(thiazol-5-yl)-1H-imidazol-2-yl)phenyl)-3-nitropyridin-2-amine
There total 6 articles about N-(4-(1-(6-methylpyridin-3-yl)-4-(thiazol-5-yl)-1H-imidazol-2-yl)phenyl)-3-nitropyridin-2-amine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: pyridinium hydrobromide perbromide; hydrogen bromide; acetic acid / 15 h / 20 °C
2.1: potassium hydrogencarbonate / tert-butyl alcohol / 17 h / 50 °C
2.2: 0.33 h / 90 °C
3.1: caesium carbonate / tris-(dibenzylideneacetone)dipalladium(0); 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 2.5 h / 150 °C
With
pyridinium hydrobromide perbromide; hydrogen bromide; potassium hydrogencarbonate; caesium carbonate; acetic acid;
tris-(dibenzylideneacetone)dipalladium(0); 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene;
In
1,4-dioxane; tert-butyl alcohol;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: triethylamine / dichloromethane / 18 h / 0 - 20 °C
2.1: trichlorophosphate / 18 h / 105 °C
2.2: 1.75 h / 0 - 20 °C
3.1: potassium hydrogencarbonate / tert-butyl alcohol / 17 h / 50 °C
3.2: 0.33 h / 90 °C
4.1: caesium carbonate / tris-(dibenzylideneacetone)dipalladium(0); 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 2.5 h / 150 °C
With
potassium hydrogencarbonate; caesium carbonate; triethylamine; trichlorophosphate;
tris-(dibenzylideneacetone)dipalladium(0); 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene;
In
1,4-dioxane; dichloromethane; tert-butyl alcohol;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: trichlorophosphate / 18 h / 105 °C
1.2: 1.75 h / 0 - 20 °C
2.1: potassium hydrogencarbonate / tert-butyl alcohol / 17 h / 50 °C
2.2: 0.33 h / 90 °C
3.1: caesium carbonate / tris-(dibenzylideneacetone)dipalladium(0); 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 2.5 h / 150 °C
With
potassium hydrogencarbonate; caesium carbonate; trichlorophosphate;
tris-(dibenzylideneacetone)dipalladium(0); 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene;
In
1,4-dioxane; tert-butyl alcohol;
