Technology Process of (1R,2S,3R)-3-tosyloxymethyl-2-pentyl-1-cyclopentanol
There total 10 articles about (1R,2S,3R)-3-tosyloxymethyl-2-pentyl-1-cyclopentanol which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
pyridine;
In
dichloromethane;
at 0 ℃;
for 9h;
- Guidance literature:
-
Multi-step reaction with 9 steps
1: 81 percent / CuI / diethyl ether / 3.5 h / -30 °C
2: 86.6 percent / pyridine / 3.5 h / Ambient temperature
3: 76.1 percent / K2CO3 / 50 °C
4: 1.) CuI, 2.) 10percent aq. NaOH / 1.) ether, -20 deg C, 30 min, 2.) MeOH, RT, 3 h
5: 1.) O3, 2.) borane-dimethyl sulfide complex, 3.) 5percent aq. HCl
6: 82.3 percent / pyridine / Ambient temperature
7: 85.6 percent / lithium bis(trimethylsilyl)amide / tetrahydrofuran / 1 h / -78 - 20 °C
8: 83.7 percent / LiAlH4 / diethyl ether / 1 h / Ambient temperature
9: 61.7 percent / pyridine / CH2Cl2 / 9 h / 0 °C
With
pyridine; hydrogenchloride; sodium hydroxide; copper(l) iodide; lithium aluminium tetrahydride; dimethylsulfide borane complex; potassium carbonate; ozone; lithium hexamethyldisilazane;
In
tetrahydrofuran; diethyl ether; dichloromethane;
- Guidance literature:
-
Multi-step reaction with 9 steps
1: 81 percent / CuI / diethyl ether / 3.5 h / -30 °C
2: 86.6 percent / pyridine / 3.5 h / Ambient temperature
3: 76.1 percent / K2CO3 / 50 °C
4: 1.) CuI, 2.) 10percent aq. NaOH / 1.) ether, -20 deg C, 30 min, 2.) MeOH, RT, 3 h
5: 1.) O3, 2.) borane-dimethyl sulfide complex, 3.) 5percent aq. HCl
6: 82.3 percent / pyridine / Ambient temperature
7: 85.6 percent / lithium bis(trimethylsilyl)amide / tetrahydrofuran / 1 h / -78 - 20 °C
8: 83.7 percent / LiAlH4 / diethyl ether / 1 h / Ambient temperature
9: 61.7 percent / pyridine / CH2Cl2 / 9 h / 0 °C
With
pyridine; hydrogenchloride; sodium hydroxide; copper(l) iodide; lithium aluminium tetrahydride; dimethylsulfide borane complex; potassium carbonate; ozone; lithium hexamethyldisilazane;
In
tetrahydrofuran; diethyl ether; dichloromethane;
