2-(4-bromo-2-fluorobenzyl)-4-ethoxycarbonyl-1,3-dioxo-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine-4-acetic acid tert-butyl ester

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Chemical Name:2-(4-bromo-2-fluorobenzyl)-4-ethoxycarbonyl-1,3-dioxo-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine-4-acetic acid tert-butyl ester
CAS No.:147193-96-2
Molecular Formula:C₂₃H₂₄BrFN₂O₆
Molecular Weight:523.356
Hs Code.:

Synonyms:2-(4-bromo-2-fluorobenzyl)-4-ethoxycarbonyl-1,3-dioxo-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine-4-acetic acid tert-butyl ester

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Chemical Property of 2-(4-bromo-2-fluorobenzyl)-4-ethoxycarbonyl-1,3-dioxo-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine-4-acetic acid tert-butyl ester

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Technology Process of 2-(4-bromo-2-fluorobenzyl)-4-ethoxycarbonyl-1,3-dioxo-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine-4-acetic acid tert-butyl ester

There total 4 articles about 2-(4-bromo-2-fluorobenzyl)-4-ethoxycarbonyl-1,3-dioxo-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine-4-acetic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.3%

: 5292-43-3
bromoacetic acid tert-butyl ester

: (4-bromo-2-fluorophenyl)methanamine mono HCl salt

: 147193-89-3
2-(2-trichloroacetylpyrrol-1-yl)malonic acid diethyl ester

: 147193-96-2
2-(4-bromo-2-fluorobenzyl)-4-ethoxycarbonyl-1,3-dioxo-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine-4-acetic acid tert-butyl ester

Guidance literature:: With triethylamine; In N-methyl-acetamide; hexane; ethyl acetate; mineral oil;

Reference yield:

: 67451-43-8
2-(pyrrol-1-yl)malonic acid diethyl ester

: 147193-96-2
2-(4-bromo-2-fluorobenzyl)-4-ethoxycarbonyl-1,3-dioxo-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine-4-acetic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 88.1 percent / CHCl₃ / 15 h / Heating

2: 86 percent / Et₃N / dimethylformamide / 15 h / Ambient temperature

3: 1.) NaH / 1.) DMF, RT, 0.5 h, 2.) DMF, RT, 2 h

With sodium hydride; triethylamine; In chloroform; N,N-dimethyl-formamide;
DOI:10.1021/jm9802968

Reference yield:

: (4-bromo-2-fluorophenyl)methanamine mono HCl salt

: 147193-96-2
2-(4-bromo-2-fluorobenzyl)-4-ethoxycarbonyl-1,3-dioxo-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine-4-acetic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 86 percent / Et₃N / dimethylformamide / 15 h / Ambient temperature

2: 1.) NaH / 1.) DMF, RT, 0.5 h, 2.) DMF, RT, 2 h

With sodium hydride; triethylamine; In N,N-dimethyl-formamide;
DOI:10.1021/jm9802968