6,7-dimethoxy-4-phenylisoquinoline

Base Information

Chemical Name:6,7-dimethoxy-4-phenylisoquinoline
CAS No.:108973-36-0
Molecular Formula:C₁₇H₁₅NO₂
Molecular Weight:265.312
Hs Code.:

Synonyms:6,7-dimethoxy-4-phenylisoquinoline

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Chemical Property of 6,7-dimethoxy-4-phenylisoquinoline

Chemical Property:

Purity/Quality:

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Technology Process of 6,7-dimethoxy-4-phenylisoquinoline

There total 5 articles about 6,7-dimethoxy-4-phenylisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₂H₂₇NO₅

: 108973-36-0
6,7-dimethoxy-4-phenylisoquinoline

Guidance literature:: With 2,3-dicyano-5,6-dichloro-p-benzoquinone; In tetrahydrofuran; at 20 ℃; for 8h; Inert atmosphere; Molecular sieve;
DOI:10.1021/acs.orglett.7b03776

Reference yield:

: 198204-67-0
2-bromo-4,5-dimethoxybenzaldehyde oxime

: 108973-36-0
6,7-dimethoxy-4-phenylisoquinoline

Guidance literature:: Multi-step reaction with 4 steps

1: zinc; hydrogenchloride / ethanol; water / 2 h / 0 - 20 °C / Inert atmosphere

2: triethylamine / dichloromethane / 4 h / 0 - 20 °C / Inert atmosphere

3: palladium diacetate; 1,1'-bis(di-tertbutylphosphino)ferrocene; cesium fluoride; tributyltin fluoride / toluene / 2 h / 100 °C

4: 2,3-dicyano-5,6-dichloro-p-benzoquinone / tetrahydrofuran / 8 h / 20 °C / Inert atmosphere; Molecular sieve

With hydrogenchloride; 1,1'-bis(di-tertbutylphosphino)ferrocene; palladium diacetate; tributyltin fluoride; triethylamine; cesium fluoride; 2,3-dicyano-5,6-dichloro-p-benzoquinone; zinc; In tetrahydrofuran; ethanol; dichloromethane; water; toluene;
DOI:10.1021/acs.orglett.7b03776

Reference yield:

: 5392-10-9
2-bromo-4,5-dimethoxybenzaldehyde

: 108973-36-0
6,7-dimethoxy-4-phenylisoquinoline

Guidance literature:: Multi-step reaction with 5 steps

1: hydroxylamine hydrochloride; sodium hydrogencarbonate / ethanol; water / 12 h / 20 °C / Inert atmosphere

2: zinc; hydrogenchloride / ethanol; water / 2 h / 0 - 20 °C / Inert atmosphere

3: triethylamine / dichloromethane / 4 h / 0 - 20 °C / Inert atmosphere

4: palladium diacetate; 1,1'-bis(di-tertbutylphosphino)ferrocene; cesium fluoride; tributyltin fluoride / toluene / 2 h / 100 °C

5: 2,3-dicyano-5,6-dichloro-p-benzoquinone / tetrahydrofuran / 8 h / 20 °C / Inert atmosphere; Molecular sieve

With hydrogenchloride; 1,1'-bis(di-tertbutylphosphino)ferrocene; hydroxylamine hydrochloride; palladium diacetate; tributyltin fluoride; sodium hydrogencarbonate; triethylamine; cesium fluoride; 2,3-dicyano-5,6-dichloro-p-benzoquinone; zinc; In tetrahydrofuran; ethanol; dichloromethane; water; toluene;
DOI:10.1021/acs.orglett.7b03776