7-(4'-chloro-biphenyl-4-sulfonylamino)-8-methoxy-1,2,4,5-tetrahydro-benzo[d]azepine-3-carboxylic acid tert-butyl ester

Base Information

• Chemical Name: 7-(4'-chloro-biphenyl-4-sulfonylamino)-8-methoxy-1,2,4,5-tetrahydro-benzo[d]azepine-3-carboxylic acid tert-butyl ester
• CAS No.: 956140-80-0
• Molecular Formula: C₂₈H₃₁ClN₂O₅S
• Molecular Weight: 543.084

Synonyms:7-(4'-chloro-biphenyl-4-sulfonylamino)-8-methoxy-1,2,4,5-tetrahydro-benzo[d]azepine-3-carboxylic acid tert-butyl ester

Chemical Property of 7-(4'-chloro-biphenyl-4-sulfonylamino)-8-methoxy-1,2,4,5-tetrahydro-benzo[d]azepine-3-carboxylic acid tert-butyl ester

Chemical Property:

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Technology Process of 7-(4'-chloro-biphenyl-4-sulfonylamino)-8-methoxy-1,2,4,5-tetrahydro-benzo[d]azepine-3-carboxylic acid tert-butyl ester

There total 1 articles about 7-(4'-chloro-biphenyl-4-sulfonylamino)-8-methoxy-1,2,4,5-tetrahydro-benzo[d]azepine-3-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

7-amino-8-methoxy-1,2, 4, 5-tetrahydro-3-benzazepine-3-carboxylic acid tert-butyl ester (583025-98-3) + 4'-chlorobiphenyl-4-sulfonyl chloride (20443-74-7) → 7-(4'-chloro-biphenyl-4-sulfonylamino)-8-methoxy-1,2,4,5-tetrahydro-benzo[d]azepine-3-carboxylic acid tert-butyl ester (956140-80-0)

Guidance literature:

With pyridine; In dichloromethane; at 20 ℃; for 12h;

DOI:10.1016/j.bmcl.2006.10.036

Reference yield: 78.0%

7-(4'-chloro-biphenyl-4-sulfonylamino)-8-methoxy-1,2,4,5-tetrahydro-benzo[d]azepine-3-carboxylic acid tert-butyl ester (956140-80-0) → 4'-chloro-biphenyl-4-sulfonic acid (8-methoxy-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-yl)-amide (732982-31-9)

Guidance literature:

With hydrogenchloride; In ethanol; at 20 ℃; for 2h;

DOI:10.1016/j.bmcl.2006.10.036

Reference yield:

7-(4'-chloro-biphenyl-4-sulfonylamino)-8-methoxy-1,2,4,5-tetrahydro-benzo[d]azepine-3-carboxylic acid tert-butyl ester (956140-80-0) → 4'-chloro-biphenyl-4-sulfonic acid (8-methoxy-3-methyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-yl)-amide

Guidance literature:

Multi-step reaction with 2 steps

1: 78 percent / HCl / ethanol / 2 h / 20 °C

2: NaBH(OAc)3; Et₃N / H₂O; 1,2-dichloro-ethane / 12 h / 20 °C

With hydrogenchloride; sodium tris(acetoxy)borohydride; triethylamine; In ethanol; water; 1,2-dichloro-ethane;

DOI:10.1016/j.bmcl.2006.10.036

upstream raw materials:

7-amino-8-methoxy-1,2, 4, 5-tetrahydro-3-benzazepine-3-carboxylic acid tert-butyl ester

4'-chlorobiphenyl-4-sulfonyl chloride

Downstream raw materials:

4'-chloro-biphenyl-4-sulfonic acid (8-methoxy-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-yl)-amide

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