isoMHPG

Base Information

• Chemical Name: isoMHPG
• CAS No.: 40979-91-7
• Molecular Formula: C9H12O4
• Molecular Weight: 184.192
• Hs Code.: 2909499000
• Mol file: 40979-91-7.mol

Synonyms:Isomhpg;Isohydroxymethoxyphenylglycol;1,2-Ethanediol,1-(3-hydroxy-4-methoxyphenyl);Isomethoxyhydroxyphenylglycol;4-Methoxy-3-hydroxyphenylethylene glycol;

Chemical Property of isoMHPG

Chemical Property:

• Vapor Pressure: 1.5E-07mmHg at 25°C
• Boiling Point: 412.7°C at 760 mmHg
• Flash Point: 203.4°C
• PSA: 69.92000
• Density: 1.311g/cm³
• LogP: 0.42650

Purity/Quality:

99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of isoMHPG

There total 7 articles about isoMHPG which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

1-(3-benzyloxy-4-methoxyphenyl)ethane-1,2-diol (213466-80-9) → 1-(3-hydroxy-4-methoxyphenyl)ethane-1,2-diol (40979-91-7)

Guidance literature:

With hydrogen; palladium on activated charcoal; for 1h; under 760 Torr; Ambient temperature;

DOI:10.1080/00397919808004875

Reference yield:

guaiacylglycerol-β-guaiacyl ether (7382-59-4) → 1-(3-hydroxy-4-methoxyphenyl)ethane-1,2-diol (40979-91-7) + 1-(3-hydroxy-4-methoxyphenyl)-2-hydroxyethanone (90536-46-2) + vanillin (121-33-5,8014-42-4) + 2-methoxy-phenol (90-05-1)

Guidance literature:

With dihydrogen peroxide; In acetonitrile; at 80 ℃; for 3h; Reagent/catalyst;

DOI:10.33224/rrch.2020.65.11.02

Reference yield:

isovanillin (621-59-0) → 1-(3-hydroxy-4-methoxyphenyl)ethane-1,2-diol (40979-91-7)

Guidance literature:

Multi-step reaction with 4 steps

1: 1.) potassium tert-butoxide / 1.) THF, room temperature, 1 h, 2.) THF, room temperature, 24 h

2: 89 percent / K₂CO₃ / acetone / 48 h / Heating

3: 70 percent / aq. K₂Os₂(OH)4, K₃Fe(CN)6, K₂CO₃ / 2-methyl-propan-2-ol / 65 h / Ambient temperature

4: 100 percent / H₂ / Pd/C / 1 h / 760 Torr / Ambient temperature

With potassium osmate; potassium tert-butylate; hydrogen; potassium carbonate; potassium hexacyanoferrate(III); palladium on activated charcoal; In acetone; tert-butyl alcohol;

DOI:10.1080/00397919808004875

upstream raw materials:

1-(3-benzyloxy-4-methoxyphenyl)ethane-1,2-diol

isovanillin

2-(3-benzyloxy-4-methoxyphenyl)ethylene

3-hydroxy-4-methoxystyrene

Refernces

• 1、 Cardinal, Sébastien,Paquet-C?té, Pierre-Alexandre,Azelmat, Jabrane,Bouchard, Corinne,Grenier, Daniel,Voyer, Normand. "Synthesis and anti-inflammatory activity of isoquebecol". . p. 2043 - 2056. Retrieved 2017/03/23.