(3-(8-(6-(2-methylpyrrolidin-1-yl)pyridin-2-ylamino)imidazo[1,2-b]pyridazin-6-yl)phenyl)(morpholino)methanone

Base Information

Chemical Name:(3-(8-(6-(2-methylpyrrolidin-1-yl)pyridin-2-ylamino)imidazo[1,2-b]pyridazin-6-yl)phenyl)(morpholino)methanone
CAS No.:1431772-92-7
Molecular Formula:C₂₇H₂₉N₇O₂
Molecular Weight:483.573
Hs Code.:

Synonyms:(3-(8-(6-(2-methylpyrrolidin-1-yl)pyridin-2-ylamino)imidazo[1,2-b]pyridazin-6-yl)phenyl)(morpholino)methanone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (3-(8-(6-(2-methylpyrrolidin-1-yl)pyridin-2-ylamino)imidazo[1,2-b]pyridazin-6-yl)phenyl)(morpholino)methanone

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (3-(8-(6-(2-methylpyrrolidin-1-yl)pyridin-2-ylamino)imidazo[1,2-b]pyridazin-6-yl)phenyl)(morpholino)methanone

There total 6 articles about (3-(8-(6-(2-methylpyrrolidin-1-yl)pyridin-2-ylamino)imidazo[1,2-b]pyridazin-6-yl)phenyl)(morpholino)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 110-91-8,99108-56-2
morpholine

: 1431772-59-6
3-(8-(6-(2-methylpyrrolidin-1-yl)pyridin-2-ylamino)imidazo[1,2-b]pyridazin-6-yl)benzoic acid

: 1431772-92-7
(3-(8-(6-(2-methylpyrrolidin-1-yl)pyridin-2-ylamino)imidazo[1,2-b]pyridazin-6-yl)phenyl)(morpholino)methanone

Guidance literature:: With 1-methyl-1H-imidazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃; for 20h;

Reference yield:

: 1431773-71-5
methyl 3-(8-bromoimidazo[1,2-b]pyridazin-6-yl)benzoate

: 1431772-92-7
(3-(8-(6-(2-methylpyrrolidin-1-yl)pyridin-2-ylamino)imidazo[1,2-b]pyridazin-6-yl)phenyl)(morpholino)methanone

Guidance literature:: Multi-step reaction with 3 steps

1.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; caesium carbonate / 1,4-dioxane / 16 h / 100 °C / Inert atmosphere

2.1: sodium hydroxide; water / 1,4-dioxane / 2 h / 40 °C

2.2: pH 4

3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 1-methyl-1H-imidazole / N,N-dimethyl-formamide; dichloromethane / 20 h / 20 °C

With 1-methyl-1H-imidazole; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; water; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1431772-58-5
methyl 3-(8-(6-(2-methylpyrrolidin-1-yl)pyridin-2-ylamino)imidazo[1,2-b]pyridazin-6-yl)benzoate

: 1431772-92-7
(3-(8-(6-(2-methylpyrrolidin-1-yl)pyridin-2-ylamino)imidazo[1,2-b]pyridazin-6-yl)phenyl)(morpholino)methanone

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydroxide; water / 1,4-dioxane / 2 h / 40 °C

1.2: pH 4

2.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 1-methyl-1H-imidazole / N,N-dimethyl-formamide; dichloromethane / 20 h / 20 °C

With 1-methyl-1H-imidazole; water; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;