N-{2-chloro-4-[(1-cyclobutyl-4-piperidinyl)oxy]benzoyl}-5-fluoro-isoindoline

Base Information

Chemical Name:N-{2-chloro-4-[(1-cyclobutyl-4-piperidinyl)oxy]benzoyl}-5-fluoro-isoindoline
CAS No.:685565-67-7
Molecular Formula:C₂₄H₂₆ClFN₂O₂
Molecular Weight:428.934
Hs Code.:

Synonyms:N-{2-chloro-4-[(1-cyclobutyl-4-piperidinyl)oxy]benzoyl}-5-fluoro-isoindoline

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-{2-chloro-4-[(1-cyclobutyl-4-piperidinyl)oxy]benzoyl}-5-fluoro-isoindoline

Chemical Property:

Purity/Quality:

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Technology Process of N-{2-chloro-4-[(1-cyclobutyl-4-piperidinyl)oxy]benzoyl}-5-fluoro-isoindoline

There total 5 articles about N-{2-chloro-4-[(1-cyclobutyl-4-piperidinyl)oxy]benzoyl}-5-fluoro-isoindoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 685565-15-5
5-fluoro-2,3-dihydro-1H-isoindole hydrochloride

: 685565-38-2
2-chloro-4-[(1-cyclobutyl-4-piperidinyl)oxy]benzoyl chloride hydrochloride

: 685565-67-7
N-{2-chloro-4-[(1-cyclobutyl-4-piperidinyl)oxy]benzoyl}-5-fluoro-isoindoline

Guidance literature:: With polystyrene-CH₂NEt₂; In dichloromethane; at 20 ℃; for 16h;

Reference yield:

: 55831-04-4
1,2-bis(bromomethyl)-4-fluorobenzene

: 685565-67-7
N-{2-chloro-4-[(1-cyclobutyl-4-piperidinyl)oxy]benzoyl}-5-fluoro-isoindoline

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / toluene / 4 h / Heating / reflux

2: hydrogenchloride; hydrogen / palladium(II) hydroxide/carbon / ethanol; water / 18 h / 45 °C / 2585.81 Torr

3: polystyrene-CH₂NEt₂ / dichloromethane / 16 h / 20 °C

With hydrogenchloride; polystyrene-CH₂NEt₂; hydrogen; triethylamine; palladium(II) hydroxide/carbon; In ethanol; dichloromethane; water; toluene;

Reference yield:

: 685565-14-4
N-benzyl-5-fluoroisoindoline

: 685565-67-7
N-{2-chloro-4-[(1-cyclobutyl-4-piperidinyl)oxy]benzoyl}-5-fluoro-isoindoline

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride; hydrogen / palladium(II) hydroxide/carbon / ethanol; water / 18 h / 45 °C / 2585.81 Torr

2: polystyrene-CH₂NEt₂ / dichloromethane / 16 h / 20 °C

With hydrogenchloride; polystyrene-CH₂NEt₂; hydrogen; palladium(II) hydroxide/carbon; In ethanol; dichloromethane; water;